Rising standards for tuberculosis drug development
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Personal computing and communication devices such as computers, personal digital assistants (PDAs), and mobile phones are moving to their next generation in which the end user will be able to access a multitude of information with a single device either lo ...
The term 'microbial persistence' describes a phenomenon whereby microorganisms which are drug-susceptible when tested outside the body are nevertheless capable of surviving within the body despite intensive therapy with the appropriate antimicrobial drug. ...
Fundamentally, the development of software applications involves dealing with two distinct domains: the real world and software domains; the two converge at the point where a software application is used to make an unsatisfactory real world situation into ...
The discovery of new metal-based antitumor drugs, whether cisplatin derivs. or those based on other metals, has been largely based on cell viability assays (IC50 values) and compds. that bind to DNA. This approach has been applied for more than 30 years du ...
The success of Mycobacterium tuberculosis as a pathogen is largely attributable to its ability to persist in host tissues, where drugs that are rapidly bactericidal in vitro require prolonged administration to achieve comparable effects. Latency is a frequ ...
Tuberculosis-control programmes are compromised by the increased frequency of multidrug-resistant strains of Mycobacterium tuberculosis. We used the polymerase chain reaction (PCR) and single-strand conformation polymorphism (SSCP) analysis techniques to e ...
Materials for use in controlled release of water sol. macromol. drugs, such as proteins and polysaccharides, were developed, i.e. (1) a material that would be phase compatible with the water sol. drug; (2) a material that would induce a reduced inflammator ...
