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Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin

Related publications (72)

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Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways

Bruno Lemaitre

Invertebrates lack an adaptive immune system and rely on innate immunity to resist pathogens. The response of Drosophila melanogaster to bacterial and fungal infections involves two signaling pathways, Toll and Imd, both of which activate members of the nu ...

Humana Press2008

Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis

Michele De Palma, Ferdinando Pucci

The use of type I interferons (IFNs) in cancer therapy has been limited by ineffective dosing and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2-expressing monocytes (TEMs) to deliver IFN-alpha to tumors. By transpl ...

2008

Toll-like receptors--taking an evolutionary approach

Bruno Lemaitre

The Toll receptor was initially identified in Drosophila melanogaster for its role in embryonic development. Subsequently, D. melanogaster Toll and mammalian Toll-like receptors (TLRs) have been recognized as key regulators of immune responses. After ten y ...

2008

A serpin that regulates immune melanization in the respiratory system of Drosophila

Bruno Lemaitre

Epithelial tissues facing the external environment are essential to combating microbial infection. In addition to providing a physical barrier, epithelial tissues mount chemical defenses to prevent invasion of internal tissues by pathogens. Here, we descri ...

2008

Artificial immune system for the Internet

Slavisa Sarafijanovic

We investigate the usability of the Artificial Immune Systems (AIS) approach for solving selected problems in computer networks. Artificial immune systems are created by using the concepts and algorithms inspired by the theory of how the Human Immune Syste ...

EPFL2008

Artificial Immune System For Collaborative Spam Filtering

Jean-Yves Le Boudec, Slavisa Sarafijanovic

Artificial immune systems (AIS) use the concepts and algorithms inspired by the theory of how the human immune system works. This document presents the design and initial evaluation of a new artificial immune system for collaborative spam filtering. Collab ...

Springer Verlag2008

Pore-forming toxins and cellular non-immune defenses (CNIDs)

Françoise Gisou van der Goot Grunberg

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxin and are important for bacterial pathogenesis. Recent studies have shown that the previous model stating that epithelial cells lyse in response to these toxins and have no defen ...

Elsevier2007

Weakened [corrected] taste-LPS association during endotoxin tolerance

Raphaël Doenlen

In naive individuals, the administration of bacterial lipopolysaccharide (LPS) provokes a rapid systemic increase in pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6, inducing an acute phase response inc ...

Elsevier2007

The host defense of Drosophila melanogaster

Bruno Lemaitre

To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense reactions, many of which are shared with higher organisms. These reactions include the use of physical barriers together with local and systemic immune responses. ...

Annual Reviews2007

Artificial Immune System For Collaborative Spam Filtering

Jean-Yves Le Boudec, Slavisa Sarafijanovic

2007