The relation between the general intellect of schizophrenic patients and psychopathological deterioration
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Endophenotypes are of crucial interest for schizophrenia research linking genetic abnormalities to pathology. During the last NCCR period, we have characterized one endophenotype, based on visual backward masking deficits, behaviourally and genetically (po ...
Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the ...
A fundamental trait of the human self is its continuum experience of space and time. Perceptual aberrations of this spatial and temporal continuity is a major characteristic of schizophrenia spectrum disturbances – including schizophrenia, schizotypal pers ...
In visual backward masking, a briefly presented target is followed by a mask, which impairs target discrimination. Backward masking is strongly impaired in schizophrenic patients and their unaffected relatives. We found that masking deficits correlated wel ...
Schizophrenia research has focused on single mechanisms mainly. Classically, a paradigm is chosen, such as a cognitive or perceptual test. The outcome is usually that schizophrenia patients perform worse than controls. Substantial research is then spent to ...