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Atropisomers as well as CC2 epimers of complestatin and chloropeptin I are readily synthesized through an intramol. SNAr reaction and the Suzuki-Miyaura reaction. The abs. configuration of amino acid N-methyl-2-(3,5-dichloro-4-hydroxyphenyl)glycine was found to det. the atropselectivity of the aryl-aryl bond-forming reaction. [on SciFinder (R)]
Qian Wang, Jieping Zhu, Jian Cao, Guihua Chen