Synthesis of alpha -keto amides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides

The reaction of an aldehyde, an isocyanide, N-methylhydroxylamine, and acetic acid in the presence of 4-.ANG. mol. sieves afforded alpha -keto amides in moderate to good yields. In contrast, 3-.ANG. mol. sieves did not promote the desired multicomponent reaction. [on SciFinder (R)]