Publication

Synthesis of dihydrophenanthridines by a sequence of Ugi-4CR and palladium-catalyzed intramolecular C-H functionalization

Jieping Zhu
2008
Journal paper

Abstract

The Ugi reaction of an o-iodobenzaldehyde, an aniline, an isocyanide, and a carboxylic acid afforded alpha -acetamido-alpha -phenylacetamide in good to excellent yields. The palladium-catalyzed intramol. C-H functionalization of these adducts under ligandless conditions provided the functionalized dihydrophenanthridines. Conclusion: Highly functionalized dihydrophenanthridines are synthesized in only two steps from readily accessible starting materials in good to excellent overall yields. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/record/158068?ln=en

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