Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
The invention relates to the prepn. of esters R1R2NCH2CH(Nu)CO2R3 (R1-R3 are protecting groups and Nu is a nucleophilic group) by reaction of R1R2NCH(CH2-Y)CO2R3 (Y is a leaving group) with a nucleophile. Thus, treatment of (R)-Bn2NCH(CH2O3SMe)CO2Me with NaN3 in MeCN afforded 90% (S)-Bn2NCH2CH(N3)CO2Me. [on SciFinder (R)]
Jérôme Waser, Eliott Hugo Joran Le Du, Julien Aymeric Borrel