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Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

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Paul Joseph Dyson, Rosario Scopelliti, Alexey Nazarov, Mathurin Baquié, Daniel Gardini
2013

Abstract

Two hybrid compounds comprising an antimetastatic rutheniumarene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.

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https://infoscience.epfl.ch/entities/publication/1580a498-9052-433b-bd9f-327758a9e310

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