Publication

Solid-phase synthesis of natural product-like macrocycles by a sequence of Ugi-4CR and SNAr-based cycloetherification

Jieping Zhu
2003
Journal paper

Abstract

An on-resin Ugi four-component reaction followed by an intramol. nucleophilic arom. substitution (SNAr) has been developed for the rapid access to biaryl-ether contg. macrocycles. Supported isocyanide was prepd. and used together with heptanal, butylamine, and 3-hydroxyphenylacetic acid for on-resin Ugi four-component reaction. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/record/158137?ln=en

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