Publication

Total synthesis of complestatin (Chloropeptin II)

Jieping Zhu, Zhiye Wang
2010
Journal paper

Abstract

Complestatin was isolated in 1980 from the mycelium of Streptomyces lavendulae as inhibitor of alternative pathways to the complement cascade. An efficient synthesis of complestatin was developed. Intramol. Suzuki-Miyaura and SNAr reactions were employed for the construction of two macrocycles by the formation of aryl-aryl and aryl-aryl ether bonds, resp. A [3+3] segment coupling was used for the construction of the hexapeptide backbone, which makes this synthesis highly convergent. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/record/158227?ln=en

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Total synthesis of complestatin (Chloropeptin II)

Graph Chatbot

Chat with Graph Search

Direct conversion of lignin to functionalized diaryl ethers via oxidative cross-coupling

Rh-catalyzed C-H Bond Heteroarylation with Hypervalent Iodine Reagents and Pd-Catalyzed Tethered Functionalizations of Carbon-Carbon Multiple Bonds.

Stereoselective synthesis of alkyl-, aryl-, vinyl- and alkynyl-substituted Z-enamides and enol ethers

Rh-catalyzed C-H Bond Heteroarylation with Hypervalent Iodine Reagents and Pd-Catalyzed Tethered Functionalizations of Carbon-Carbon Multiple Bonds.

Direct conversion of lignin to functionalized diaryl ethers via oxidative cross-coupling

Stereoselective synthesis of alkyl-, aryl-, vinyl- and alkynyl-substituted Z-enamides and enol ethers