Publication

An efficient stereoselective and stereodivergent synthesis of (2R,3R)- and (2R,3S)-3-hydroxypipecolic acids

Jieping Zhu
2000
Journal paper

Abstract

Asymmetric syntheses of (2R,3R) and (2R,3S)-3-hydroxypipecolic acids are reported featuring a key diastereoselective addition of Büchi's Grignard reagent to the chiral serinal Image -5. Based on conformational analysis, a stereocontrolled reduction of piperidin-3-one (15) to cis 2,3-disubstituted piperidine (16) is also described.

Official source

https://infoscience.epfl.ch/record/158315?ln=en

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An efficient stereoselective and stereodivergent synthesis of (2R,3R)- and (2R,3S)-3-hydroxypipecolic acids

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