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Cell-responsive hydrogel for encapsulation of vascular cells

Related publications (33)

Hybrid hydrogels for load-bearing implants

Load-bearing tissues such as articular cartilage or meniscus are not infallible. They might fail due to trauma, over-solicitations, or diseases, which could subsequently alter the mobility of the patient. Repairing these damaged tissues in a minimally inva ...

EPFL2021

Three dimensional models of tissue fibrosis

Kristina Schoonjans, Matthias Lütolf, Giovanni Sorrentino, Saba Rezakhani, Ece Yildiz

The invention provides a method for obtaining a three-dimensional (3D) cellular model of tissue fibrosis, such as liver fibrosis, comprising culturing epithelial cells in a 3D hydrogel in conditions suitable for a three-dimensional cellular cluster formati ...

2020

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Peyman Karami, Andreas Schmocker, Azadeh Khoushabi, Céline Samira Wyss, Martin Broome

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...

2018

Three dimensional hydrogels for culturing organoids

Matthias Lütolf, Nikolche Gjorevski

The invention provides hydrogels and methods for three-dimensional (3D) culture of adult epithelial stem cells and uses thereof. ...

2017

Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation

Sandrine Gerber, François Rémi Pierre Noverraz, Jutta Christine Wandrey, Solène Marcelle Françoise Marie Passemard, Luca Szabó

The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...

Amer Chemical Soc2017

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Azadeh Khoushabi

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

Photo-polymerization, swelling and mechanical properties of cellulose fibre reinforced poly(ethylene glycol) hydrogels

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi

The application of hydrogels as load-bearing biomedical components is often limited by their mechanical properties. Often an attempt to improve a hydrogel's stiffness is accompanied by a loss of toughness and swelling properties. In this work, we show that ...

Elsevier Sci Ltd2015

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies

Davide Demurtas, Jeffrey Alan Hubbell, Edward Allen Phelps, Carrie Ellen Brubaker

With proper control over copolymer design and solvation conditions, self-assembled materials display impressive morphological variety that encompasses nanoscale colloids as well as bulk three-dimensional architectures. Here we take advantage of both hydrop ...

Amer Chemical Soc2015

Post-operative monitoring of free muscle transfers by Laser Doppler Imaging: A prospective study

Dimitri Nestor Alice Van De Ville

PurposeDespite different existing methods, monitoring of free muscle transfer is still challenging. In the current study we evaluated our clinical setting regarding monitoring of such tissues, using a recent microcirculation-imaging camera (EasyLDI) as an ...

Wiley-Blackwell2015

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