Asymptotic computational complexityIn computational complexity theory, asymptotic computational complexity is the usage of asymptotic analysis for the estimation of computational complexity of algorithms and computational problems, commonly associated with the usage of the big O notation. With respect to computational resources, asymptotic time complexity and asymptotic space complexity are commonly estimated. Other asymptotically estimated behavior include circuit complexity and various measures of parallel computation, such as the number of (parallel) processors.
Sanger sequencingSanger sequencing is a method of DNA sequencing that involves electrophoresis and is based on the random incorporation of chain-terminating dideoxynucleotides by DNA polymerase during in vitro DNA replication. After first being developed by Frederick Sanger and colleagues in 1977, it became the most widely used sequencing method for approximately 40 years. It was first commercialized by Applied Biosystems in 1986. More recently, higher volume Sanger sequencing has been replaced by next generation sequencing methods, especially for large-scale, automated genome analyses.
Parameterized complexityIn computer science, parameterized complexity is a branch of computational complexity theory that focuses on classifying computational problems according to their inherent difficulty with respect to multiple parameters of the input or output. The complexity of a problem is then measured as a function of those parameters. This allows the classification of NP-hard problems on a finer scale than in the classical setting, where the complexity of a problem is only measured as a function of the number of bits in the input.
Massive parallel sequencingMassive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing (NGS) or second-generation sequencing. Some of these technologies emerged between 1993 and 1998 and have been commercially available since 2005. These technologies use miniaturized and parallelized platforms for sequencing of 1 million to 43 billion short reads (50 to 400 bases each) per instrument run.
Graphic matroidIn the mathematical theory of matroids, a graphic matroid (also called a cycle matroid or polygon matroid) is a matroid whose independent sets are the forests in a given finite undirected graph. The dual matroids of graphic matroids are called co-graphic matroids or bond matroids. A matroid that is both graphic and co-graphic is sometimes called a planar matroid (but this should not be confused with matroids of rank 3, which generalize planar point configurations); these are exactly the graphic matroids formed from planar graphs.
Neighbourhood (graph theory)In graph theory, an adjacent vertex of a vertex v in a graph is a vertex that is connected to v by an edge. The neighbourhood of a vertex v in a graph G is the subgraph of G induced by all vertices adjacent to v, i.e., the graph composed of the vertices adjacent to v and all edges connecting vertices adjacent to v. The neighbourhood is often denoted N_G (v) or (when the graph is unambiguous) N(v). The same neighbourhood notation may also be used to refer to sets of adjacent vertices rather than the corresponding induced subgraphs.
Nucleic acid hybridizationIn molecular biology, hybridization (or hybridisation) is a phenomenon in which single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules anneal to complementary DNA or RNA. Though a double-stranded DNA sequence is generally stable under physiological conditions, changing these conditions in the laboratory (generally by raising the surrounding temperature) will cause the molecules to separate into single strands. These strands are complementary to each other but may also be complementary to other sequences present in their surroundings.
Whole genome sequencingWhole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014.
Euler methodIn mathematics and computational science, the Euler method (also called the forward Euler method) is a first-order numerical procedure for solving ordinary differential equations (ODEs) with a given initial value. It is the most basic explicit method for numerical integration of ordinary differential equations and is the simplest Runge–Kutta method. The Euler method is named after Leonhard Euler, who first proposed it in his book Institutionum calculi integralis (published 1768–1870).
Polynomial long divisionIn algebra, polynomial long division is an algorithm for dividing a polynomial by another polynomial of the same or lower degree, a generalized version of the familiar arithmetic technique called long division. It can be done easily by hand, because it separates an otherwise complex division problem into smaller ones. Sometimes using a shorthand version called synthetic division is faster, with less writing and fewer calculations. Another abbreviated method is polynomial short division (Blomqvist's method).
