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Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including atherosclerosis. We investigated the regulation of arginase pathway in response to distinct patterns of wall shear stress.
Jacques Fellay, Christian Axel Wandall Thorball, Stéphane Fournier, Roxane De La Harpe
Stéphane Joost, Idris Guessous, David Nicolas De Ridder, Guillaume Jordan