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A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells

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A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells

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Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and BCR-ABL1(T315I-E255K)

Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression

Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

Allosteric kinase inhibitors

Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics

Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy

Allosteric regulation and targeting of Abl SH2-kinase interface and other cytoplasmic tyrosine kinases