A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor

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Influence of channel geomorphic units on bedload transport and river morphology during low‐magnitude bed‐forming floods coupled with sediment augmentation

Giovanni De Cesare, Severin Stähly, Christian Mörtl, Robin Schroff

In this study, we map different types of channel geomorphic units in a sediment-starved, residual-flow reach before and after an artificial flood. Bedload particles of a previous sediment augmentation measure are tracked with passive integrated transponder ...

2023

Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

Cathrin Brisken, Carlos Henrique Venturi Ronchi

The presurgical window of opportunity trial (WOT) MIPRA provides evidence that neoadjuvant treatment with the prog-esterone receptor (PR) antagonist mifepristone (RU486) may benefit patients with estrogen receptor-positive (ER+) breast cancer characterized ...

AMER ASSOC CANCER RESEARCH2023

Atomistic modeling of C-S-H: bulk and surface

Ziga Casar

By replacing part of Portland cement with so-called supplementary cementitious materials (SCMs) it is possible to reduce the CO2 footprint of the cement industry. These SCMs are commonly limestone, calcined clay, slag and fly ash. While doing so the early ...

EPFL2023

Balancing NAD(+) deficits with nicotinamide riboside: therapeutic possibilities and limitations

Carlos Canto Alvarez

Alterations in cellular nicotinamide adenine dinucleotide (NAD(+)) levels have been observed in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that dietary supplementation with NAD(+) precursors, or vitamin B3s, could ...

SPRINGER BASEL AG2022

NAD(+) Precursors: A Questionable Redundancy

Carlos Canto Alvarez

The last decade has seen a strong proliferation of therapeutic strategies for the treatment of metabolic and age-related diseases based on increasing cellular NAD(+) bioavailability. Among them, the dietary supplementation with NAD(+) precursors-classicall ...

MDPI2022

The role of nicotinamide riboside metabolism in pancreatic beta cells

Angélique Satoko Cercillieux

Pancreatic beta cells play a major role in the regulation of glucose homeostasis by secreting insulin in response to elevated blood glucose levels. A gradual deterioration of functional beta cell mass and the chronic elevation of blood glucose levels are c ...

EPFL2022

Sense of agency for intracortical brain-machine interfaces

Olaf Blanke, Andrea Serino, Tommaso Enrico Bertoni, Nathan Quentin Faivre, Marco Solcà, Pavo Orepic, Gaurav Sharma

Intracortical brain-machine interfaces decode motor commands from neural signals and translate them into actions, enabling movement for paralysed individuals. The subjective sense of agency associated with actions generated via intracortical brain-machine ...

NATURE PORTFOLIO2022

Microscopic interplay of temperature and disorder of a one-dimensional elastic interface

Elisabeth Agoritsas, Thierry Giamarchi

Elastic interfaces display scale-invariant geometrical fluctuations at sufficiently large lengthscales. Their asymptotic static roughness then follows a power-law behavior, whose associated exponent provides a robust signature of the universality class to ...

2022

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Clara Bonnet

Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...

BMC2022

Determining patterns of post-stroke motor recovery through longitudinal multimodal MRI: A step towards patient stratification

Julia Brügger

Motivated by the need for a better understanding of post-stroke recovery and new biomarkers to improve stroke patient stratification and outcomes, this thesis investigated structure-function coupling and its role in post-stroke recovery. Furthermore, in or ...

EPFL2022

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Influence of channel geomorphic units on bedload transport and river morphology during low‐magnitude bed‐forming floods coupled with sediment augmentation

Giovanni De Cesare, Severin Stähly, Christian Mörtl, Robin Schroff

2023

Determining patterns of post-stroke motor recovery through longitudinal multimodal MRI: A step towards patient stratification

Julia Brügger

EPFL2022