Overlapping geneAn overlapping gene (or OLG) is a gene whose expressible nucleotide sequence partially overlaps with the expressible nucleotide sequence of another gene. In this way, a nucleotide sequence may make a contribution to the function of one or more gene products. Overlapping genes are present and a fundamental feature of both cellular and viral genomes. The current definition of an overlapping gene varies significantly between eukaryotes, prokaryotes, and viruses.
Single-nucleotide polymorphismIn genetics and bioinformatics, a single-nucleotide polymorphism (SNP snɪp; plural SNPs snɪps) is a germline substitution of a single nucleotide at a specific position in the genome that is present in a sufficiently large fraction of considered population (generally regarded as 1% or more). For example, a G nucleotide present at a specific location in a reference genome may be replaced by an A in a minority of individuals. The two possible nucleotide variations of this SNP – G or A – are called alleles.
Fixed effects modelIn statistics, a fixed effects model is a statistical model in which the model parameters are fixed or non-random quantities. This is in contrast to random effects models and mixed models in which all or some of the model parameters are random variables. In many applications including econometrics and biostatistics a fixed effects model refers to a regression model in which the group means are fixed (non-random) as opposed to a random effects model in which the group means are a random sample from a population.
ThunkIn computer programming, a thunk is a subroutine used to inject a calculation into another subroutine. Thunks are primarily used to delay a calculation until its result is needed, or to insert operations at the beginning or end of the other subroutine. They have many other applications in compiler code generation and modular programming. The term originated as a whimsical irregular form of the verb think. It refers to the original use of thunks in ALGOL 60 compilers, which required special analysis (thought) to determine what type of routine to generate.
Human evolutionary geneticsHuman evolutionary genetics studies how one human genome differs from another human genome, the evolutionary past that gave rise to the human genome, and its current effects. Differences between genomes have anthropological, medical, historical and forensic implications and applications. Genetic data can provide important insights into human evolution. Biologists classify humans, along with only a few other species, as great apes (species in the family Hominidae).
Random effects modelIn statistics, a random effects model, also called a variance components model, is a statistical model where the model parameters are random variables. It is a kind of hierarchical linear model, which assumes that the data being analysed are drawn from a hierarchy of different populations whose differences relate to that hierarchy. A random effects model is a special case of a mixed model.
Common LispCommon Lisp (CL) is a dialect of the Lisp programming language, published in American National Standards Institute (ANSI) standard document ANSI INCITS 226-1994 (S20018) (formerly X3.226-1994 (R1999)). The Common Lisp HyperSpec, a hyperlinked HTML version, has been derived from the ANSI Common Lisp standard. The Common Lisp language was developed as a standardized and improved successor of Maclisp. By the early 1980s several groups were already at work on diverse successors to MacLisp: Lisp Machine Lisp (aka ZetaLisp), Spice Lisp, NIL and S-1 Lisp.
Isolated pointIn mathematics, a point x is called an isolated point of a subset S (in a topological space X) if x is an element of S and there exists a neighborhood of x that does not contain any other points of S. This is equivalent to saying that the singleton {x} is an open set in the topological space S (considered as a subspace of X). Another equivalent formulation is: an element x of S is an isolated point of S if and only if it is not a limit point of S.
HIVThe human immunodeficiency viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype.
Restriction fragment length polymorphismIn molecular biology, restriction fragment length polymorphism (RFLP) is a technique that exploits variations in homologous DNA sequences, known as polymorphisms, populations, or species or to pinpoint the locations of genes within a sequence. The term may refer to a polymorphism itself, as detected through the differing locations of restriction enzyme sites, or to a related laboratory technique by which such differences can be illustrated.
