Publication

CYP3A activity measured by the midazolam test is not related to 3435 C >T polymorphism in the multiple drug resistance transporter gene

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The variability of terminal restriction fragment polymorphism analysis applied to complex microbial communities was assessed statistically. Recent technological improvements were implemented in the successive steps of the procedure, resulting in a standard ...

American Society for Microbiology2009

Cyclosporin analogues

Arnaud Hamel

Cyclosporins are a family of hydrophobic cyclic undecapeptides produced by the fungus Tolypocladium niveum. The main metabolite cyclosporin A (CsA, see Scheme, R = R' = H) is the first line drug currently used to prevent rejection of organ transplants. Its ...

EPFL2005

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To measure the in vivo variations of CYP3A activity induced by anti-HIV drugs in human immunodeficiency virus (HIV)1-positive patients ...

Springer Verlag2005

Cyclosporin is a cyclic undecapeptide useful as drug for organ transplantation due to its immunosuppressive properties. Ten years ago, an anti-viral activity was discovered, incompatible with immunosuppression. These two activities originate in the presenc ...

EPFL2004

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The reverse transcriptase inhibitor efavirenz is currently used at a fixed dose of 600 mg/d. However, dosage individualization based on plasma concentration monitoring might be indicated. This study aimed to assess the efavirenz pharmacokinetic profile and ...

Elsevier2003

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HIV-1-infected patients vary considerably by their response to antiretroviral treatment, drug concentrations in plasma, toxic events, and rate of immune recovery. This variability could have a genetic basis. We did a pharmacogenetics study to analyse the a ...

Elsevier2002

The Bradford chromatic adaptation transform, empirically derived by Lam, models illumination change. Specifically, it provides a means of mapping XYZs under a reference source to XYZs for a target light such that the corresponding XYZs produce the same per ...

2000

The Bradford chromatic adaptation transform, empirically derived by Lam, models illumination change. Specifically, it pro-vides a means of mapping XYZs under a reference light source to XYZs for a target light source such that the corresponding XYZs produc ...

2000