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Two cases of neonatal group B streptococcal (GBS) infection occurring in a large consanguineous kindred are described. The observation suggests that susceptibility to isolated GBS disease in this family may have been the result of an inborn error of immuni ...
Infectious diseases pose a serious threat to public health due to its high infectivity and potentially high mortality. One of the most effective ways to protect people from being infected by these diseases is through vaccination. However, due to various re ...
Les progrès actuels dans la connaissance des variations génétiques humaines et de leurs conséquences fonctionnelles permettent de mieux comprendre la bataille millénaire que se livrent l'homme et les microbes. De nombreux polymorphismes modulant notre répo ...
Vaccination is one of the most effective ways to protect people from being infected by infectious disease. However, it is often impractical to vaccinate all people in a community due to various resource constraints. Therefore, targeted vaccination, which v ...
We describe a protocol for the discovery of synergistic drug combinations for the treatment of disease. Synergistic drug combinations lead to the use of drugs at lower doses, which reduces side effects and can potentially lead to reduced drug resistance, w ...
Relentless progress in our knowledge of the nature and functional consequences of human genetic variation allows for a better understanding of the protracted battle between pathogens and their human hosts. Multiple polymorphisms have been identified that i ...
An explanation for the spatial variability of seasonal cholera patterns has remained an unresolved problem in tropical medicine. No simple and unified theory based on local climate variables has been formulated, leaving our understanding of seasonal variati ...
Infectious diseases, both in their endemic and epidemic forms, have shaped the human genome. Ecology has also contributed to geographically constrained pressures on human populations. There are now multiple examples of population-specific genetic variants ...
Epidemiological models can provide crucial understanding about the dynamics of infectious diseases. Possible applications range from real-time forecasting and allocation of health care resources to testing alternative intervention mechanisms such as vaccin ...
The dynamics of infectious diseases spread via direct person-to-person transmission (such as influenza, smallpox, HIV/AIDS, etc.) depends on the underlying host contact network. Human contact networks exhibit strong community structure. Understanding how s ...
