Influence of imagined posture and imagery modality on corticospinal excitability

Single pulse transcranial magnetic stimulation (TMS) was used to test the assumption that kinesthetic imagery of action is more 'motor' than visual imagery of action. We assessed corticospinal excitability during motor imagery of a thumb-palm opposition movement by recording potentials evoked by TMS from two hand muscles that would (opponens pollicis, OP, target) or would not (abductor digiti minimi, ADM, control) be activated during actual performance of the very same movement. Participants were asked to imagine the thumb-palm opposition movement while maintaining first person imagery that was either purely visual or predominately kinesthetic. The motor imagery task was performed in two conditions in which the imagined and the actual hand could be either congruent or incongruent. Facilitation of potentials recorded from OP was higher during imagery carried out in mentally congruent than incongruent postures. This effect was largely due to lack of excitability recorded during incongruent kinesthetic imagery, which was indistinguishable from baseline imagery of the static hand. All other conditions differed from static imagery regardless of position. No significant effects were found in a control muscle (ADM) thus indicating that the effect was not related to spatial coding. Subjective reports obtained after the experiment indicate that the results cannot be ascribed to qualitative differences in the imagery experienced. For relatively simple motor tasks requiring no 'expertise' we found no detectable difference in the motor cortex due to imagery modality.

Generalization of motor resonance during the observation of hand, mouth, and eye movements

Michela Bassolino

Transcranial magnetic stimulation (TMS) of the motor cortex shows that hand action observation (AO) modulates corticospinal excitability (CSE). CSE modulation alternatively maps low-level kinematic characteristics or higher-level features, like object-directed action goals. However, action execution is achieved through the control of muscle synergies, consisting of coordinated patterns of muscular activity during natural movements, rather than single muscles or object-directed goals. This synergistic organization of action execution also underlies the ability to produce the same functional output (i.e., grasping an object) using different effectors. We hypothesize that motor system activation during AO may rely on similar principles. To investigate this issue, we recorded both hand CSE and TMS-evoked finger movements which provide a much more complete description of coordinated patterns of muscular activity. Subjects passively watched hand, mouth and eyelid opening or closing, which are performing non-object-directed (intransitive) actions. Hand and mouth share the same potential to grasp objects, whereas eyelid does not allow object-directed (transitive) actions. Hand CSE modulation generalized to all effectors, while TMS evoked finger movements only to mouth AO. Such dissociation suggests that the two techniques may have different sensitivities to fine motor modulations induced by AO. Differently from evoked movements, which are sensitive to the possibility to achieve object-directed action, CSE is generically modulated by "opening" vs. "closing" movements, independently of which effector was observed. We propose that motor activities during AO might exploit the same synergistic mechanisms shown for the neural control of movement and organized around a limited set of motor primitives.

Amer Physiological Soc2015

Hand perceptions induced by single pulse transcranial magnetic stimulation over the primary motor cortex

Michela Bassolino, Olaf Blanke, Matteo Franza, Andrea Serino, Giuliana Sorrentino, Matteo Vissani

Background When single pulse transcranial magnetic stimulation (TMS) is applied over the primary motor cortex (M1) with sufficient intensity, it evokes muscular contractions (motor-evoked potentials, MEPs) and muscle twitches (TMS-evoked movements). Participants may also report various hand sensations related to TMS, but the perception elicited by TMS and its relationship to MEPs and evoked movements has not been systematically studied. Objective The main aim of this work is to evaluate participants' kinesthetic and somatosensory hand perceptions elicited by single-pulse TMS over M1-hand area at different intensities of stimulation and their relation with MEPs and TMS-evoked movements. Methods We compared the number of MEPs (measured by electromyography), TMS-evoked movements (measured by an accelerometer) and participants' hand perception (measured by verbal report) elicited by TMS at different intensity of stimulation. This way, we estimated the amplitude of MEPs and the acceleration of TMS-evoked movements sufficient to trigger TMS evoked hand perceptions. Results We found that TMS-evoked hand perceptions are induced at 105% of the individual resting motor threshold, a value significantly different from the threshold inducing MEPs (about 100%) and TMS-evoked movements (about 110%). Our data indicate that only MEPs with an amplitude higher than 0.62 mV and TMS-evoked movements with acceleration higher than 0.42 m/s2 were associated with hand perceptions at threshold. Conclusions Our data reveal the main features of TMS-evoked hand perception and show that in addition to MEPs and TMS-evoked movements, this is a separate discernible response associated to single-pulse TMS over M1.

2019