Yimon Aye, Sruthi Raja, Jesse Poganik, Yi Zhao, Kuan-Ting Huang
The mechanism-of-action of many electrohilic drugs remains poorly understood. Here, the authors use a redox-targeting approach to elucidate the basis for the innate immune cell toxicity of dimethyl fumarate, showing that it modifies Keap1 to trigger mitoch ...
NATURE PORTFOLIO2021