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Study of the effect of rapid pacing of atrial fibrillation on the non-paced atrium

Jean-Marc Vesin, Laurent Renaud Uldry, Lukas Kappenberger
2011
Conference paper
Abstract

Purpose: Experimental studies showed that local capture of atrial fibrillation (AF) by rapid pacing was possible in humans. However, contradictory observations were reported on its effect at distant atrial sites. The present model-based study investigated the effect of rapid pacing on the paced and the non-paced atria. Methods: A biophysical model of AF based on a geometry from human MRI and a membrane kinetics model was used. Rapid AF pacing was applied during 30s in right atrial (RA) free wall or left atrial (LA) appendage at optimal pacing cycle lengths based on previous studies (RA:76 ms, LA:77ms). The pacing effect was characterized by measuring 256 electrograms evenly located in RA and LA, from which the following values were computed: AF cycle length (AFCL), number of wavefronts (#WF), percentage of excited tissue (ET) and AF organization index (OI) assessing spectral regularity and ranging from 0 to 1. Results: Pacing successfully induced local AF capture in the paced atrium with an AFCL close to the pacing cycle length. Local capture was accompanied by a significant (p

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Ontological neighbourhood
Health sciences
Related concepts (20)
Artificial cardiac pacemaker
An artificial cardiac pacemaker (artificial pacemaker, and sometimes just pacemaker, although the term is also used to refer to the body's natural cardiac pacemaker) is a medical device, nowadays always implanted, that generates electrical pulses delivered by electrodes to one or more of the chambers of the heart, the upper atria or lower ventricles. Each pulse causes the targeted chamber(s) to contract and pump blood, thus regulating the function of the electrical conduction system of the heart.
Atrial fibrillation
Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm (arrhythmia) characterized by rapid and irregular beating of the atrial chambers of the heart. It often begins as short periods of abnormal beating, which become longer or continuous over time. It may also start as other forms of arrhythmia such as atrial flutter that then transform into AF. Episodes can be asymptomatic. Symptomatic episodes may involve heart palpitations, fainting, lightheadedness, shortness of breath, or chest pain.
Implantable cardioverter-defibrillator
An implantable cardioverter-defibrillator (ICD) or automated implantable cardioverter defibrillator (AICD) is a device implantable inside the body, able to perform defibrillation, and depending on the type, cardioversion and pacing of the heart. The ICD is the first-line treatment and prophylactic therapy for patients at risk for sudden cardiac death due to ventricular fibrillation and ventricular tachycardia. "AICD" was trademarked by the Boston Scientific corporation, so the more generic "ICD" is preferred terminology.
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