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The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
Related publications (43)
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AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...
EPFL2022Biogeography and biochemistry of bile acid 7-dehydroxylation in the mammalian gut
Bile acids (BAs) are small molecules synthesized by the host and chemically modified by the microorganisms inhabiting the intestinal tract. The microbial transformation of BAs in the gut is critical to BA-mediated signaling as it modifies their amount and ...
EPFL2020NTCP deficiency in mice protects against obesity and hepatosteatosis
Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na+ taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma. R ...
AMER SOC CLINICAL INVESTIGATION INC2019Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
A large number of glucagon-like-peptide-1(GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs s ...
AMER PHYSIOLOGICAL SOC2019beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue
beta-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb(-/-)mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we inv ...
Amer Soc Clinical Investigation Inc2017Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo
Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...
EPFL2017Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells
Kristina Schoonjans, Alessia Perino
Bile acids and epithelial-derived human beta-defensins (H beta Ds) are known to be important factors in the regulation of colonic mucosal barrier function and inflammation. We hypothesized that bile acids regulate colonic H beta D expression and aimed to t ...
Federation of American Society of Experimental Biology2017PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis
We report the engineering and characterization of paraoxonase-3 knockout mice (Pon3KO). The mice were generally healthy but exhibited quantitative alterations in bile acid metabolism and a 37% increased body weight compared to the wild-type mice on a high ...
Federation of American Society of Experimental Biology2015Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells
Kristina Schoonjans, Alessia Perino, Yasmine Sebti
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces glucago ...
Nature Publishing Group2015