Background: Small molecule ligands often have multiple effects on the transcriptional program of a cell: they trigger a receptor specific response and additional, indirect responses ("side effects"). Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals.
Didier Trono, Priscilla Turelli, Charlène Mireille Raymonde Raclot
Johan Auwerx, Sébastien Robert Victor Herzig, Adrienne Joëlle Laurence Mottis