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Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain
Related publications (32)
Live-cell imaging powered by computation
The proliferation of microscopy methods for live-cell imaging offers many new possibilities for users but can also be challenging to navigate. The prevailing challenge in live-cell fluorescence microscopy is capturing intra-cellular dynamics while preservi ...
Berlin2024Orchestrating chromosome conformation capture analysis with Bioconductor
Genome-wide chromatin conformation capture assays provide formidable insights into the spatial organization of genomes. However, due to the complexity of the data structure, their integration in multi-omics workflows remains challenging. We present data st ...
2024From Automated Bootstrapping to Collaborative Editing: A Framework for 4D City Reconstruction
Rémi Guillaume Petitpierre, Paul Robert Guhennec, Beatrice Vaienti, Didier Louis Dupertuis
We propose a framework for the construction of 4D scientific models for cities of the past. It leverages both the use of computational methods for bootstrapping, and a collaborative interface for visualisation and edition. This permits to continuously enri ...
Zenodo2023Computational tools and resources for designing new pathways to small molecules
Vassily Hatzimanikatis, Anastasia Sveshnikova
The metabolic engineering community relies on computational methods for pathway design to produce important small molecules in microbial hosts. Metabolic network databases are continuously curated and updated with known and novel reactions that expand the ...
CURRENT BIOLOGY LTD2022Current challenges in understanding the role of enhancers in disease
Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There is growing eviden ...
NATURE PORTFOLIO2022Reconstruction of the Hippocampus
Henry Markram, Felix Schürmann, Armando Romani, Michele Migliore
The hippocampus is a widely studied brain region thought to play an important role in higher cognitive functions such as learning, memory, and navigation. The amount of data on this region increases every day and delineates a complex and fragmented picture ...
Springer2022Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells
We present dyngen, a multi-modal simulation engine for studying dynamic cellular processes at single-cell resolution. dyngen is more flexible than current single-cell simulation engines, and allows better method development and benchmarking, thereby stimul ...
NATURE RESEARCH2021Comparison of computational methods for the electrochemical stability window of solid-state electrolyte materials
Aris Marcolongo, Matthieu Gilles Mottet
Superior stability and safety are key promises attributed to all-solid-state batteries (ASSBs) containing solid-state electrolyte (SSE) compared to their conventional counterparts utilizing liquid electrolyte. To unleash the full potential of ASSBs, SSE ma ...
ROYAL SOC CHEMISTRY2020A Computational Method for Identifying the Optimum Buffer Size in the Era of Zero Defect Manufacturing
Decreasing defects, waste time, meeting customer demand and being adaptable are the goals of a Zero Defect Manufacturing (ZDM) strategy. Scheduling is an important tool to perform that. It should take in account buffer size allocation. In this study, a met ...
SPRINGER INTERNATIONAL PUBLISHING AG2020The Past, Present and Future of Digital Scholarship with Newspaper Collections
Maud Ehrmann, Giovanni Colavizza
Historical newspapers are of interest to many humanities scholars as sources of information and language closely tied to a particular time, social context and place. Digitised newspapers are also of interest to many data-driven researchers who seek large b ...
2019