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Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
Related publications (39)
Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization
Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer
Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...
FRONTIERS MEDIA SA2022Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth
Michele De Palma, Nadine Fournier, Stefanie Siegert, Mauro Delorenzi, Mario Leonardo Squadrito, Sina Nassiri, Pascale Anderle Pedone, Simone Ragusa, François Renevey
Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...
London2022Modeling metabolic and signaling pathways in cancer cells
Cancer is a leading cause of death in the world, and the mechanisms that underlie this disease are still not completely understood. As cancer develops and progresses, cells undergo a diversity of mutations that sustain their rapid proliferation and the eva ...
EPFL2020Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies
Mechanistic modeling of signaling pathways mediating patient-specific response to therapy can help to unveil resistance mecha-nisms and improve therapeutic strategies. Yet, creating suchmodels for patients, in particular for solid malignancies, is chal-len ...
2020Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2
Nadine Fournier, Mauro Delorenzi, Sina Nassiri, Borja Prat Luri, Laureline Wetterwald
Calcineurin/NFAT signaling is active in endothelial cells and is proposed to be an essential component of the tumor angiogenic response. Here, we investigated the role of endothelial calcineurin signaling in vivo in physiological and pathological angiogene ...
CELL PRESS2019Anti-angiogenic immunotherapy for lung cancer
Lung cancer is the leading cause of cancer-associated deaths worldwide. Platinum-based chemotherapy is the most common therapeutic approach in advanced non-small cell lung cancer (NSCLC), particularly for tumors that carry non-druggable activating mutation ...
EPFL2019Consensus guidelines for the use and interpretation of angiogenesis assays
Michele De Palma, George Coukos, Patrycja Nowak-Sliwinska, Elizabeth Anne Allen, Yan Gong
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that ...
2018Microenvironmental regulation of tumour angiogenesis
Michele De Palma, Daniela Biziato
Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cel ...
Nature Publishing Group2017Oxygen-17 dynamic nuclear polarisation enhanced solid-state NMR spectroscopy at 18.8 T
Frédéric Blanc, David Lyndon Emsley, David Benjamin Roger Antoine Gajan
We report O-17 dynamic nuclear polarisation (DNP) enhanced solid-state NMR experiments at 18.8 T. Several formulations were investigated on the Mg(OH)(2) compound. A signal enhancement factor of 17 could be obtained when the solid particles were incorporat ...
2017Design principles for therapeutic angiogenic materials
Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez
Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis - the proc ...
Nature Publishing Group2016