Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers
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Peptide based and peptide hybrid materials represent two interesting and challenging classes of biomaterials. Both classes consist of and contain, respectively, one or more polypeptide blocks, endowing the resulting polymers with enhanced self-assembly pro ...
BACKGROUND: We present the synthesis, characterization and initial structure-function analysis of a new class of bioactive agent that allows the application of techniques from colloid science to biological surfaces. Stable colloidal suspensions can be gene ...
Carrier-mediated drug delivery has emerged as a powerful methodology for the treatment of various pathologies. The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue ...
Block copolymers are comprised of repeating chemical groups (blocks) which commonly contain at least one hydrophilic block coupled to at least one hydrophobic block, forming an amphipathic macromolecule. This molecular arrangement drives the self assembly ...
Effective encapsulation of small, volatile, weakly water-soluble molecules such as flavors and fragrances is necessary to protect them from degradation, to increase their lifetime, and to improve their water dispersion and fixation depending on the substra ...
The envelopes of spin-echo amplitudes obtained with trains of multiple refocusing pulses are normally modulated by homonuclear scalar couplings. Echo modulations make it difficult to determine transverse relaxation rate constants R2. Provided that the puls ...
This report describes the aqueous solution self-assembly of a series of polystyrenem-b-poly(L-lysine)n block copolymers (m = 8-10; n = 10-70). The polymers are prepared by ring-opening polymerization of e-benzyloxycarbonyl-L-lysine AT-carboxyanhydride usin ...
Using a refocused INADEQUATE NMR experiment we show that homonuclear carbon-carbon through-bond correlations can be obtained in disordered organic solids where the line widths greatly exceed the value of the scalar coupling. The feasibility of the experime ...
The elastic properties of rod-coil diblock copolymer poly(styrene-d8)-b-poly(γ-benzyl L-glutamate) (PSd-b-PBLG) rod-coil diblock copolymer solutions were investigated using small-angle neutron scattering (SANS). PBLG is known to undergo a transition from a ...
The preparation of synthetic polymers with exact control over chain length and monomer sequence is one of the long-standing challenges in polymer science. Nature perfectly masters the synthesis of high molecular weight, perfectly monodisperse polypeptides ...