Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P-1 and P-2) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules encapsulated in the arene-ruthenium metalla-cage, Ru-6(p-cymene)(6) (tpt)(2)(donq)(3) (1) (tpt=2,4,6-tri-(pyridin-4-yl)-1,3,5-triazine; donq=5,8-dioxydo-1,4-naphthoquinonato). The host-guest properties of P-1 subset of 1 and P-2 subset of 1 were studied in solution by NMR and UV/Vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water-soluble host-guest systems was evaluated on human ovarian cancer cells.
Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Muhammad Hanif
Paul Joseph Dyson, Tina Riedel, Alexander Tskhovrebov
Paul Joseph Dyson, Mylène Soudani, Catherine Marie Amélie Clavel, Emilia Paunescu