Accurate and Fast Simulation of Channel Noise in Conductance-Based Model Neurons by Diffusion Approximation
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The neocortex is one of the most evolved and complex region of the brain. For more than a century scientists have been curious about the neocortex, to identify the anatomical blueprint of its cellular organization and to understand its role in higher brain ...
The evolutionary transition from water to land required new locomotor modes and corresponding adjustments of the spinal "central pattern generators" for locomotion. Salamanders resemble the first terrestrial tetrapods and represent a key animal for the stu ...
The coordinated, collective spiking activity of neuronal populations encodes and processes information. One approach towards understanding such population based computation is to fit statistical models to simultaneously recorded spike trains and use these ...
2010
Statistical models of neural activity are integral to modern neuroscience. Recently interest has grown in modeling the spiking activity of populations of simultaneously recorded neurons to study the effects of correlations and functional connectivity on ne ...
Massachusetts Institute of Technology Press2011
Statistical models of neural activity are at the core of the field of modern computational neuroscience. The activity of single neurons has been modeled to successfully explain dependencies of neural dynamics to its own spiking history, to external stimuli ...
Opinions strongly diverge on what constitutes a good model of a neuron. Two lines of thought on this have coexisted for a long time: detailed biophysical models (of the style proposed in 1952 by the physiologists Alan Hodgkin and Andrew Huxley) that descri ...
The estimation of doubly-selective channels is challenging since long channel impulse response should be estimated with a fast tracking speed. Provided that a structure of the channel response is sparse, i.e., only a few of channel gains are nonzero, a tra ...
2009
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The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column. L5b pyramidal cells have been the subject of extensive experimental and modeling ...
The ability of simple mathematical models to predict the activity of single neurons is important for computational neuroscience. In neurons, stimulated by a time-dependent current or conductance, we want to predict precisely the timing of spikes and the su ...
A path-integral approach is developed for the analysis of spike-triggered-average quantities in neurons with voltage-gated subthreshold currents. Using a linearization procedure to reduce the models to the generalized integrate-and-fire form, analytical ex ...