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Hypoxia Impairs Skin Myofibroblast Differentiation and Function
Related publications (34)
First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting
Biranche Tandon, Nicolas Tissot
In vitro skin models are validated methods for screening cosmetics and pharmaceuticals, but still have limitations. The bilayer poly(epsilon-caprolactone) scaffold/membrane model described here overcomes some of these deficits by integrating a solution ele ...
Weinheim2024Enhancing Robustness of Adhesive Hydrogels through PEG-NHS Incorporation
Dominique Pioletti, Theofanis Stampoultzis, Yanheng Guo, Ece Uslu, François Gorostidi, Vijay Kumar Rana
Tissue wounds are a significant challenge for the healthcare system, affecting millions globally. Current methods like suturing and stapling have limitations as they inadequately cover the wound, fail to prevent fluid leakage, and increase the risk of infe ...
Washington2023Promising eco-friendly biomaterials for future biomedicine: Cleaner production and applications of Nanocellulose
Cellulose nanomaterials are developing nowadays as a promising environmental friendlier biomaterial that can be extracted from native plant sources. These materials, because of their excellent physico-chemical and biological properties, urged much interest ...
ELSEVIER2021Microstructured Biodegradable Fibers for Advanced Control Delivery
Fabien Sorin, Alexis Gérald Page, Andreas Leber, Inès Richard, Govindan Narayanan Krishnamani, Shahrzad Shadman Yazdi, Jurgis Ruza
Biodegradable polymers are increasingly employed at the heart of therapeutic devices. Particularly in the form of thin and elongated fibers, they offer an effective strategy for controlled release in a variety of biomedical configurations such as sutures, ...
WILEY-V C H VERLAG GMBH2020Surface and bulk stresses drive morphological changes in fibrous microtissues
Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas
Engineered fibrous tissues consisting of cells encapsulated within collagen gels are widely used three-dimensional (3D) in vitro models of morphogenesis and wound healing. While cell-mediated matrix remodeling that occurs within these scaffolds has been ex ...
2019Soft Self-Healing Nanocomposites
Véronique Michaud, Yves Leterrier, Sravendra Rana
This review article provides an overview of the research and applications of soft self-healing polymers and their nanocomposites. A number of concepts based on physical and chemical interactions have been explored to create dynamic and reversible gel and e ...
FRONTIERS MEDIA SA2019Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes
Diabetic foot ulcerations (DFUs) represent a major medical, social, and economic problem. Therapeutic options are restricted due to a poor understanding of the pathogenic mechanisms. The Notch pathway plays a pivotal role in cell differentiation, prolifera ...
2019Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling
Jeffrey Alan Hubbell, Melody Swartz, Witold Waldemar Kilarski, Priscilla Suhasna Maithili Briquez, Esra Güç, Manuel Andreas Fankhauser
Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growt ...
2017Group Decisions Influence Emergence and Regulation of Leaders during Collective Migration of Epithelial Cells
Collective migration is a central event involving coordinated movement of several individuals. One of the critical events during collective migration is the emergence of leading individuals, who provide directional guidance for the group movement. While on ...
EPFL2017Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine
Priscilla Suhasna Maithili Briquez
Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...
EPFL2016