Publication

Development of a microfluidic on-chip reverse transcription module for the analysis of hematopoietic single stem cells

Related publications (177)

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Johan Auwerx, Richardus Houtkooper, Ivan Stamenkovic, Michalina Janiszewska

Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. ...

Cold Spring Harbor Lab Press, Publications Dept2012

High-throughput approaches for the analysis of extrinsic regulators of stem cell fate

Matthias Lütolf, Adrian Ranga

The complexity of stem cell niches poses a tremendous challenge to understanding mechanisms of extrinsic regulation of stem cell fate. In order to better understand niche signaling and its effect on stem cell fate choices, in vitro systems are being engine ...

2012

Interaction of Different Wavelengths in a Turbulent Flow within a Random Array of Rigid and Emergent Stems

Anton Schleiss, Mário Jorge Rodrigues Pereira Da Franca, Ana Margarida Da Costa Ricardo

Emergent vegetation covering floodplains and wetlands has an important role in fluvial ecosystems. Since natural systems are not homogeneous, the flow within the stem array is influenced by several space scales, determined by the number-density of stems an ...

2012

Optimization of a dynamic compression bioreactor to evaluate mechano-transduction in 3D hydrogel-encapsulated cartilage progenitor cells.

Salim Elias Darwiche

Mechanical stimuli have fundamental repercussions on a cell’s phenotype and response in vivo. Studying these effects in a controlled in vitro bioreactor system allows bioengineers to hone in on the regenerative potential of therapeutic cells to better desi ...

2012

2D Stem Cell Culture on Microfluidic Generated Hydrogel Beads

Tanja Cloé Hausherr

Stem cells capacity to self-renew and differentiate into specialized cell types, endow them with great promises in regenerative medicine. It is believed that the stem cells microenvironment plays a significant role in regulating their fate. However, with e ...

2011

Effect of fluid flow shear stress on Mesenchymal Stem Cells(MSC) differentiation using a microfluidic device

Sohrab Emami Naeini

Mesenchymal Stem Cells (MSC) are multipotent stem cells that are predominantly obtained from the bone marrow. These cells have a high ability to differentiate into a multitude of cell types, which are very attractive for tissue engineering and cell therapy ...

2011

Genomic instability in induced stem cells

Didier Trono, Marc Samuel Friedli

The ability to reprogram adult cells into stem cells has raised hopes for novel therapies for many human diseases. Typical stem cell reprogramming protocols involve expression of a small number of genes in differentiated somatic cells with the c-Myc and Kl ...

Nature Publishing Group2011

Biochips for Regenerative Medicine: Real-time Stem Cell Continuous Monitoring as Inferred by High-Throughput Gene Analysis

Giovanni De Micheli, Sandro Carrara, Giovanna Del Vecchio

Regenerative medicine is a novel clinical branch aiming at the cure of diseases by replacement of damaged tissues. The crucial use of stem cells makes this area rich of challenges, given the poorly understood mechanisms of differentiation. One highly neede ...

2011

Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

The developmental potential of human pluripotent stem cells suggests that they can produce disease-relevant cell types for biomedical research. However, substantial variation has been reported among pluripotent cell lines, which could affect their utility ...

2011

Artificial niche microarrays for probing single stem cell fate in high throughput

Matthias Lütolf, Stefan Kobel, Samy Gobaa, Andrea Negro

To understand the regulatory role of niches in maintaining stem-cell fate, multifactorial in vitro models are required. These systems should enable analysis of biochemical and biophysical niche effectors in a combinatorial fashion and in the context of a p ...

Nature Publishing Group2011

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