BRCA mutationA BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome in affected persons. Only 5–10% of breast cancer cases in women are attributed to BRCA1 and BRCA2 mutations (with BRCA1 mutations being slightly more common than BRCA2 mutations), but the impact on women with the gene mutation is more profound.
NerveA nerve is an enclosed, cable-like bundle of nerve fibers (called axons) in the peripheral nervous system. Axons transmit electrical impulses. Nerves have historically been considered the basic units of the peripheral nervous system. A nerve provides a common pathway for the electrochemical nerve impulses called action potentials that are transmitted along each of the axons to peripheral organs or, in the case of sensory nerves, from the periphery back to the central nervous system.
UltrixUltrix (officially all-caps ULTRIX) is the brand name of Digital Equipment Corporation's (DEC) discontinued native Unix operating systems for the PDP-11, VAX, MicroVAX and DECstations. The initial development of Unix occurred on DEC equipment, notably DEC PDP-7 and PDP-11 (Programmable Data Processor) systems. Later DEC computers, such as their VAX, also offered Unix. The first port to VAX, UNIX/32V, was finished in 1978, not long after the October 1977 announcement of the VAX, for which – at that time – DEC only supplied its own proprietary operating system, VMS.
Coalescent theoryCoalescent theory is a model of how alleles sampled from a population may have originated from a common ancestor. In the simplest case, coalescent theory assumes no recombination, no natural selection, and no gene flow or population structure, meaning that each variant is equally likely to have been passed from one generation to the next. The model looks backward in time, merging alleles into a single ancestral copy according to a random process in coalescence events.
OpenVMSOpenVMS, often referred to as just VMS, is a multi-user, multiprocessing and virtual memory-based operating system. It is designed to support time-sharing, batch processing, transaction processing and workstation applications. Customers using OpenVMS include banks and financial services, hospitals and healthcare, telecommunications operators, network information services, and industrial manufacturers. During the 1990s and 2000s, there were approximately half a million VMS systems in operation worldwide.
Conservation geneticsConservation genetics is an interdisciplinary subfield of population genetics that aims to understand the dynamics of genes in a population for the purpose of natural resource management and extinction prevention. Researchers involved in conservation genetics come from a variety of fields including population genetics, natural resources, molecular ecology, biology, evolutionary biology, and systematics. Genetic diversity is one of the three fundamental measures of biodiversity (along with species diversity and ecosystem diversity), so it is an important consideration in the wider field of conservation biology.
Orbit (anatomy)In anatomy, the orbit is the cavity or socket of the skull in which the eye and its appendages are situated. "Orbit" can refer to the bony socket, or it can also be used to imply the contents. In the adult human, the volume of the orbit is , of which the eye occupies . The orbital contents comprise the eye, the orbital and retrobulbar fascia, extraocular muscles, cranial nerves II, III, IV, V, and VI, blood vessels, fat, the lacrimal gland with its sac and duct, the eyelids, medial and lateral palpebral ligaments, cheek ligaments, the suspensory ligament, septum, ciliary ganglion and short ciliary nerves.
ExomeThe exome is composed of all of the exons within the genome, the sequences which, when transcribed, remain within the mature RNA after introns are removed by RNA splicing. This includes untranslated regions of messenger RNA (mRNA), and coding regions. Exome sequencing has proven to be an efficient method of determining the genetic basis of more than two dozen Mendelian or single gene disorders. The human exome consists of roughly 233,785 exons, about 80% of which are less than 200 base pairs in length, constituting a total of about 1.
