Peripheral toleranceIn immunology, peripheral tolerance is the second branch of immunological tolerance, after central tolerance. It takes place in the immune periphery (after T and B cells egress from primary lymphoid organs). Its main purpose is to ensure that self-reactive T and B cells which escaped central tolerance do not cause autoimmune disease. Peripheral tolerance prevents immune response to harmless food antigens and allergens, too.
Great BritainGreat Britain is an island in the North Atlantic Ocean off the north-west coast of continental Europe, consisting of England, Scotland and Wales. With an area of , it is the largest of the British Isles, the largest European island and the ninth-largest island in the world. It is dominated by a maritime climate with narrow temperature differences between seasons. The island of Ireland, with an area 40 per cent that of Great Britain, is to the west—these islands, along with over 1,000 smaller surrounding islands and named substantial rocks, form the British Isles archipelago.
Kingdom of Great BritainThe 'Kingdom of Great Britain, officially Great Britain', was a sovereign country in Western Europe from 1 May 1707 to the end of 31 December 1800. The state was created by the 1706 Treaty of Union and ratified by the Acts of Union 1707, which united the kingdoms of England (which included Wales) and Scotland to form a single kingdom encompassing the whole island of Great Britain and its outlying islands, with the exception of the Isle of Man and the Channel Islands.
