Publication
Hearts and bones': the ups and downs of plasticity' in stem cell biology
Related publications (61)
A pure population of ectodermal cells derived from human embryonic stem cells
Embryonic stem (ES) cells represent a unique cellular model to recapitulate in vitro early steps of embryonic development and an unlimited cellular source in therapy for many diseases, as well as targets for drug discovery and toxicology screens. Although ...
2008Isolation of hematopoietic stem cells from mouse embryonic stem cells
Olaia Maria Naveiras Torres-Quiroga
This unit describes a protocol for the isolation of cells from murine embryonic stem cells with hematopoietic stem cell activity, defined by the ability to reconstitute, long term, multiple lineages of the hematopoietic system of lethally irradiated mice. ...
Wiley2008Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency
The therapeutic potential of embryonic stem cells (ESc) is a key scientific interest, but the ethical implications of stem cell research have been controversial and are often a major detriment to the advancement of our knowledge. Recently, several landmark ...
2008Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells
In hair follicles, dermal papilla (DP) and dermal sheath (DS) cells exhibit striking levels of plasticity, as each can regenerate both cell types. Here, we show that thrombin induces a phosphoinositide 3-kinase (PI3K)-Akt pathway-dependent acquisition of D ...
Company of Biologists2008The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway
Olaia Maria Naveiras Torres-Quiroga, Zhao Chen
The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias, MYH9, encodes myosin-IIA, a protein that enables morphogenesis in diverse cell types. Defective myosin-IIA complexes are presumed to perturb megakaryocyte (MK) differentiati ...
American Society of Hematology2007Stem cells and their niche: a matter of fate
Olaia Maria Naveiras Torres-Quiroga
Embryonic stem cells provide an in vitro model for developmental biologists to study cell fate decisions during ontogenesis, while somatic stem cells allow physiologists to understand tissue homeostasis in the adult. The behavior of stem cells is dependent ...
Springer Verlag2006Low-temperature pausing of cultivated mammalian cells
Florian Maria Wurm, David Hacker, Martin Jordan, Lisa Hunt, Frédéric Grosjean
There are currently two methods for maintaining cultured mammalian cells, continuous passage at 37 degrees C and freezing in small batches. We investigated a third approach, the "pausing" of cells for days or weeks at temperatures below 37 degrees C in a v ...
2005Microplates: a new tool for manipulation and mechanical perturbation of individual cells
We present a new type of microinstrument allowing manipulation and mechanical perturbation of individual cells under an optical microscope. These instruments, which we call microplates, are pulled from rectangular glass bars. They have flat tips, typically ...
Elsevier1999Different stability of AP1 proteins in human keratinocyte and fibroblast cells: possible role in the cell-type specific expression of human papillomavirus type 18 genes
Human papillomaviruses (HPV) replicate in keratinocyte but not fibroblast cells. Several factors, including AP1 (Jun/Fos), contribute to the cell-type specific transcription of HPV genes. The binding of AP1 upstream of the HPV type 18 early gene E6 is esse ...
1993Probing spermatogenesis in Drosophila with P-element enhancer detectors
Formation of motile sperm in Drosophila melanogaster requires the coordination of processes such as stem cell division, mitotic and meiotic control and structural reorganization of a cell. Proper execution of spermatogenesis entails the differentiation of ...
1992