Reuptake inhibitorA reuptake inhibitor (RI) is a type of drug known as a reuptake modulator that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron. This leads to an increase in extracellular concentrations of the neurotransmitter and an increase in neurotransmission. Various drugs exert their psychological and physiological effects through reuptake inhibition, including many antidepressants and psychostimulants.
Transcranial direct-current stimulationTranscranial direct current stimulation (tDCS) is a form of neuromodulation that uses constant, low direct current delivered via electrodes on the head. It was originally developed to help patients with brain injuries or neuropsychiatric conditions such as major depressive disorder. It can be contrasted with cranial electrotherapy stimulation, which generally uses alternating current the same way, as well as transcranial magnetic stimulation. Research shows increasing evidence for tDCS as a treatment for depression.
OctopamineOctopamine (molecular formula C8H11NO2; also known as OA, and also norsynephrine, para-octopamine and others) is an organic chemical closely related to norepinephrine, and synthesized biologically by a homologous pathway. Octopamine is often considered the major "fight-or-flight" neurohormone of invertebrates. Its name is derived from the fact that it was first identified in the salivary glands of the octopus. In many types of invertebrates octopamine is an important neurotransmitter and hormone.
SicilySicily (Sicilia siˈtʃiːlja; Sicilia sɪˈ(t)ʃiːlja) is the largest and most populous island in the Mediterranean Sea and one of the 20 regions of Italy with the Strait of Messina dividing it from the region of Calabria in Southern Italy. It is one of the five Italian autonomous regions and is officially referred to as Regione Siciliana. The region has 4.8 million inhabitants. Its capital city is Palermo. Sicily is in the central Mediterranean Sea, south of the Italian Peninsula in continental Europe, from which it is separated by the narrow Strait of Messina.
Emirate of SicilyThe Emirate of Sicily or Fatimid Sicily (ʾImārat Ṣiqilliya) was an Islamic kingdom that ruled the Muslim territories on the island of Sicily between 831 and 1091. Its capital was Palermo (Arabic: Balarm), which, during this period, became a major cultural and political center of the Muslim world. Sicily was part of the Byzantine Empire when Muslim forces from Ifriqiya began launching raids in 652. Through a prolonged series of conflicts from 827 to 902, they gradually conquered the entirety of Sicily, with only the stronghold of Rometta, in the far northeast, holding out until 965.
Kingdom of SicilyThe Kingdom of Sicily (Regnum Siciliae; Regno di Sicilia; Regnu di Sicilia) was a state that existed in the south of the Italian Peninsula and for a time the region of Ifriqiya from its founding by Roger II of Sicily in 1130 until 1816. It was a successor state of the County of Sicily, which had been founded in 1071 during the Norman conquest of the southern peninsula. The island was divided into three regions: Val di Mazara, Val Demone and Val di Noto.
