In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues. © 2006 Elsevier Inc. All rights reserved.
Vassily Hatzimanikatis, Ljubisa Miskovic, Michaël Roger Germain Moret
Vassily Hatzimanikatis, Ljubisa Miskovic, Meriç Ataman, Tuure Eelis Hameri, Sofia Tsouka
Vassily Hatzimanikatis, Sofia Tsouka