Publication
Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 Tesla
Related publications (33)
Robust gamma-aminobutyric acid and energy metabolism measurements by proton and phosphorus magnetic resonance spectroscopy and fingerprinting
Magnetic resonance spectroscopy (MRS) is the only technique that can detect endogenous metabolites directly and non-invasively in vivo. It allows to identify different metabolites and analyze the dynamic neurochemical processes in the brain, skeletal muscl ...
EPFL2023Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy
Magnetic Resonance Spectroscopy (MRS) is the only technique capable of measuring a large number of metabolites simultaneously in vivo. Ultra-high magnetic fields (UHF) combined with ultra-short echo time (TE) sequences allow the detection of high-quality 1 ...
EPFL2022Does powder averaging remove dispersion bias in diffusion MRI diameter estimates within real 3D axonal architectures?
Marco Pizzolato, Tim Bjørn Dyrby
Noninvasive estimation of axon diameter with diffusion MRI holds the potential to investigate the dynamic properties of the brain network and pathology of neurodegenerative diseases. Recent studies use powder averaging to account for complex white matter a ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2022Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field
This thesis is composed of four studies centered on investigating cerebral metabolism using magnetic resonance spectroscopy (MRS) of hyperpolarized and non-hyperpolarized compounds at ultra-high field.
In the first two chapters, we studied longitudinally t ...
EPFL2021Genetic-Optimized Pulse Coding Technique for Brillouin Distributed Optical Fiber Sensing
Luc Thévenaz, Marcelo Alfonso Soto Hernandez, Zhisheng Yang, Simon Adrien Zaslawski, Sheng Wang, Jian Wu
A single code sequence designed by a genetic searching algorithm is proposed to enhance the signal-to-noise ratio of Brillouin distributed sensors without hardware modification, enabling high-performance and cost-effective sensing over a 200-km-loop setup. ...
2020Engineering Parallel Transmit/Receive Radio-Frequency Coil Arrays for Human Brain MRI at 7 Tesla
Magnetic resonance imaging is widely used in medical diagnosis to obtain anatomical details of the human body in a non-invasive way. Clinical MR scanners typically operate at a static magnetic field strength (B0) of 1.5T or 3T. However, going to higher fie ...
EPFL2019Impact of Fitting and Digital Filtering on Signal-to-Noise Ratio and Brillouin Frequency Shift Uncertainty of BOTDA Measurements
Luc Thévenaz, Marcelo Alfonso Soto Hernandez, Zhisheng Yang, Simon Adrien Zaslawski
The intricate relationships linking signal-to-noise ratio and Brillouin frequency shift uncertainty after post-processing of Brillouin optical time-domain analysis measurements are investigated, highlighting the crucial impact of fitting. ...
OSA2018Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes
Rolf Gruetter, Bernard Lanz, Marta Lai
The combination of dynamic (13)C MRS data under infusion of (13)C-labeled substrates and compartmental models of cerebral metabolism enabled in vivo measurement of metabolic fluxes with a quantitative and distinct determination of cellular-specific activit ...
Elsevier2017Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner
PURPOSE: Modification of a clinical MRI scanner to enable simultaneous or rapid interleaved acquisition of signals from two different nuclei. METHODS: A device was developed to modify the local oscillator signal fed to the receive channel(s) of an MRI cons ...
Wiley-Blackwell2016A double-quadrature radiofrequency coil design for proton-decoupled carbon-13 magnetic resonance spectroscopy in humans at 7T
Rolf Gruetter, Lijing Xin, Özlem Ipek, Guillaume Donati, Eulalia Serés Roig
Purpose Carbon-13 magnetic resonance spectroscopy (13C-MRS) is challenging because of the inherent low sensitivity of 13C detection and the need for radiofrequency transmission at the 1H frequency while receiving the 13C signal, the latter requiring electr ...
Wiley-Blackwell2015