Microcrystal electron diffractionMicrocrystal electron diffraction, or MicroED, is a CryoEM method that was developed by the Gonen laboratory in late 2013 at the Janelia Research Campus of the Howard Hughes Medical Institute. MicroED is a form of electron crystallography where thin 3D crystals are used for structure determination by electron diffraction. Prior to this demonstration, macromolecular (protein) electron crystallography was only used on 2D crystals, for example.
Molecular modellingMolecular modelling encompasses all methods, theoretical and computational, used to model or mimic the behaviour of molecules. The methods are used in the fields of computational chemistry, drug design, computational biology and materials science to study molecular systems ranging from small chemical systems to large biological molecules and material assemblies. The simplest calculations can be performed by hand, but inevitably computers are required to perform molecular modelling of any reasonably sized system.
Is-aAn is-a relationship is when one type of object 'is a' instance of another type of object. For example, a cat 'is a' animal, but not vice versa. All cats are animals, but not all animals are cats. The concept becomes important in object oriented programing, where 'is a' relationships are often used as a way to structure code - behaviour that are is relevant to all animals is defined on an animal class, whereas behaviour that is relevant only for cats is defined in a cat class.
Class-based programmingClass-based programming, or more commonly class-orientation, is a style of object-oriented programming (OOP) in which inheritance occurs via defining classes of objects, instead of inheritance occurring via the objects alone (compare prototype-based programming). The most popular and developed model of OOP is a class-based model, instead of an object-based model. In this model, objects are entities that combine state (i.e., data), behavior (i.e., procedures, or methods) and identity (unique existence among all other objects).
DicloxacillinDicloxacillin is a narrow-spectrum β-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible (non-resistant) Gram-positive bacteria. It is active against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise be resistant to most penicillins. Dicloxacillin is available under a variety of trade names including Diclocil (BMS). It was patented in 1961 and approved for medical use in 1968. It is available as a generic medication.
