Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity
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The effect of diln. rate on the prodn. of lactic acid from whey permeate by L. helveticus was investigated. In the 1st chemostat of a 2-stage system, total conversion (98.1%) and max. lactic acid concn. (43.7 g/L) were obtained at a diln. rate (D1tot) of 0 ...
The amt. of Vitreoscilla Hb (VHb) expression was modulated over a broad range with an isopropyl-beta-D-thiogalactopyranoside- (IPTG)- inducible plasmid, and the consequences on microaerobic Escherichia coli physiol. were examd. in glucose fed-batch cultiva ...
Evidence suggests that astrocytes might play an important role in cerebral energy metabolism. A recently developed cell line, called DI TNC1, displays several characteristic features of astrocytes. Thus, we have investigated in these cells a number of para ...
The transport of lactate is an essential part of the concept of metabolic coupling between neurons and glia. Lactate transport in primary cultures of astroglial cells was shown to be mediated by a single saturable transport system with a Km value for lacta ...
Despite striking advances in functional brain imaging, the cellular and molecular mechanisms that underlie the signals detected by these techniques are still largely unknown. The basic physiological principle of functional imaging is represented by the tig ...
Cytokines can be produced within the nervous system by various cell types, including astrocytes, which secrete them in response to pathological processes such as viral infections. Astrocytes are known to play an important role in the homeostasis of the ner ...
As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in biology and medicine. At the cellular level, the basic molecular framework for the regulation of iron uptake, storage, and utilization has been defined. Two cytop ...
Astrocytes appear to be ideally localized to couple neuronal activity to energy metabolism. First, specialized processes, the astrocytic end-feet surround blood vessels, the source of glucose for the brain. Second, other processes ensheath synapses and exp ...