A Drug Administration Decision Support System

Drug delivery is one of the most common clinical routines in hospitals, and is critical to patients’ health and recovery. It includes a decision making process in which a medical doctor decides the amount (dose) and frequency (dose interval) on the basis of a set of available patients’ feature data and the doctor’s clinical experience (a priori adaptation). This process can be computerized in order to make the prescription procedure in a fast, objective, inexpensive, non-invasive and accurate way. This paper proposes a Drug Administration Decision Support System (DADSS) to help clinicians/patients with the initial dose computing. The system is based on a Support Vector Machine (SVM) algorithm for estimation of the potential drug concentration in the blood of a patient, from which a best combination of dose and dose interval is selected at the level of a DSS. The addition of the RANdom SAmple Consensus (RANSAC) technique enhances the prediction accu- racy by selecting inliers for SVM modeling. Experiments are performed for the drug imatinib case study which shows more than 40% improvement in the prediction accuracy compared with previous works. An important extension to the patient features’ data is also proposed in this paper.

Personalized Drug Administrations Using Support Vector Machine

Giovanni De Micheli, Alena Simalatsar, Wenqi You Dubout

The decision-making process regarding drug dose, regularly used in everyday medical practice, is critical to patients’ health and recovery. It is a challenging process, especially for a drug with narrow therapeutic ranges, in which a medical doctor decides the quantity (dose amount) and frequency (dose interval) on the basis of a set of available patient features and doctor’s clinical experience (a priori adaptation). Computer support in drug dose administration makes the prescription procedure faster, more accurate, objective, and less expensive, with a tendency to reduce the number of invasive procedures. This paper presents an advanced integrated Drug Administration Decision Support System (DADSS) to help clinicians/patients with the dose computing. Based on a support vector machine (SVM) algorithm, enhanced with the random sample consensus technique, this system is able to predict the drug concentration values and computes the ideal dose amount and dose interval for a new patient. With an extension to combine the SVM method and the explicit analytical model, the advanced integrated DADSS system is able to compute drug concentration-to-time curves for a patient under different conditions. A feedback loop is enabled to update the curve with a new measured concentration value to make it more personalized (a posteriori adaptation).

2013

Drug concentration prediction and delivery

Giovanni De Micheli, Alena Simalatsar, Wenqi You Dubout

In medical practice, the decision-making process regarding drug dose is critical to patients’ health and recovery. For drugs with narrow therapeutic ranges, the medical doctor decides the quantity (dose amount) and frequency (dose interval) on the basis of a set of patients’ parameters. Computer-aided tools for drug dose administration makes the prescription procedure faster, more accurate, more objective, and less expensive. We describe an advanced integrated Drug Administration Decision Support System (DADSS) to help clinicians/patients with the dose/frequency computing. Based on a support vector machine (SVM) algorithm, enhanced with the random sample consensus technique, this system is able to predict the drug concentration values and computes the ideal dose amount and dose interval for a new patient. With an extension to combine the SVM method and the explicit analytical model, the advanced integrated DADSS system is able to compute drug concentration-to-time curves for a patient under different conditions.

2014

Classification of fall directions via wearable motion sensors

Mustafa Sahin Turan

Effective fall-detection and classification systems are vital in mitigating severe medical and economical consequences of falls to people in the fall risk groups. One class of such systems is based on wearable sensors. While there is a vast amount of academic work on this class of systems, not much effort has been devoted to the investigation of effective and robust algorithms and like-for-like comparison of state-ofthe-art algorithms using a sufficiently large dataset. In this article, fall-direction classification algorithms are presented and compared on an extensive dataset, comprising a total of 1600 fall trials. Eight machine learning classifiers are implemented for fall-direction classification into four basic directions (forward, backward, right, and left). These are, namely, Bayesian decision making (BDM), least squares method (LSM), k-nearest neighbor classifier (k-NN), artificial neural networks (ANNs), support vector machines (SVMs), decision-tree classifier (DTC), random forest (RF), and adaptive boosting or AdaBoost (AB). BDM achieves perfect classification, followed by k-NN, SVM, and RF. Data acquired from only a single motion sensor unit, worn at the waist of the subject, are processed for experimental verification. Four of the classifiers (BDM, LSM, k-NN, and ANN) are modified to handle the presence of data from an unknown class and evaluated on the same dataset. In this robustness analysis, ANN and k-NN yield accuracies above 96.2%. The results obtained in this study are promising in developing real-world fall-classification systems as they enable fast and reliable classification of fall directions.(c) 2021 Elsevier Inc. All rights reserved.

ACADEMIC PRESS INC ELSEVIER SCIENCE2022