Schaffer collateralSchaffer collaterals are axon collaterals given off by CA3 pyramidal cells in the hippocampus. These collaterals project to area CA1 of the hippocampus and are an integral part of memory formation and the emotional network of the Papez circuit, and of the hippocampal trisynaptic loop. It is one of the most studied synapses in the world and named after the Hungarian anatomist-neurologist Károly Schaffer. As a part of the hippocampal structures, Schaffer collaterals develop the limbic system, which plays a critical role in the aspects of learning and memory.
Hebbian theoryHebbian theory is a neuropsychological theory claiming that an increase in synaptic efficacy arises from a presynaptic cell's repeated and persistent stimulation of a postsynaptic cell. It is an attempt to explain synaptic plasticity, the adaptation of brain neurons during the learning process. It was introduced by Donald Hebb in his 1949 book The Organization of Behavior. The theory is also called Hebb's rule, Hebb's postulate, and cell assembly theory.
Principal ideal domainIn mathematics, a principal ideal domain, or PID, is an integral domain in which every ideal is principal, i.e., can be generated by a single element. More generally, a principal ideal ring is a nonzero commutative ring whose ideals are principal, although some authors (e.g., Bourbaki) refer to PIDs as principal rings. The distinction is that a principal ideal ring may have zero divisors whereas a principal ideal domain cannot.
Principal idealIn mathematics, specifically ring theory, a principal ideal is an ideal in a ring that is generated by a single element of through multiplication by every element of The term also has another, similar meaning in order theory, where it refers to an (order) ideal in a poset generated by a single element which is to say the set of all elements less than or equal to in The remainder of this article addresses the ring-theoretic concept.
Myasthenia gravisMyasthenia gravis (MG) is a long-term neuromuscular junction disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. Onset can be sudden. Those affected often have a large thymus or develop a thymoma. Myasthenia gravis is an autoimmune disease of the neuro-muscular junction which results from antibodies that block or destroy nicotinic acetylcholine receptors (AChR) at the junction between the nerve and muscle.
