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Microfluidics for in vitro biomimetic shear stress-dependent leukocyte adhesion assays

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Confined interfaces between cement grout and other materials such as embossed steel or rough concrete are formed in an innovative new steel-concrete connection for composite bridges. This article presents the experimental study of such interfaces and inves ...

Elsevier2014

The talk reviews some of the analytical results available for studying the dambreak problem. Emphasis is then given to a thorough comparison between experimental data, analytical results (lubrication theory), and numerical simulations (obtained using the s ...

2014

Confined flow of suspensions modelled by a frictional rheology

Brice Tanguy Alphonse Lecampion, Dmitriy Garagash

We investigate in detail the problem of confined pressure-driven laminar flow of neutrally buoyant non-Brownian suspensions using a frictional rheology based on the recent proposal of Boyer et al. (Phys. Rev. Lett., vol. 107 (18), 2011, 188301). The fricti ...

2014

Bioluminescence imaging of small biomolecules

Aurélien Godinat, Riccardo Sinisi, Grigory Karateev, Ghyslain Martial Alain Budin, Aleksandra Konovalova, Jens Tomas Frigell

The invention relates to a technique to detect small molecules using Bioluminescence imaging (BLI) to image and quantify non-invasively, in vitro and in vivo,intracellular metabolite fluxes and which can be applied to azido-modified compounds, such as azid ...

2014

EXPERIMENTAL VALIDATION OF A CONSTANT SURFACE SHEAR STRESS IN PARTICLE SALTATION LAYERS

Benjamin Andreas Walter

Owens second hypothesis [1] states that the surface shear stress induced by the fluid on the stationary sediment on the ground in a particle saltation layer equals the threshold for particle entrainment. Despite the fact that most numerical models describi ...

2013

The earth's surface is permanently exposed to the atmosphere and accordingly to strong wind forces in many regions. Aerodynamic entrainment, transport and redeposition of sand, soil or snow are able to considerably reshape the surface morphology and influe ...

EPFL2012

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In the intracellular signaling networks that regulate important cell processes, the base pattern comprises the cycle of reversible phosphorylation of a protein, catalyzed by kinases and opposing phosphatases. Mathematical modeling and analysis have been us ...

Iop Publishing Ltd2012

Hydrogel Microfluidics to Control Stem Cell Fate

Steffen Cosson

Biomolecular signaling is of utmost importance in governing many biological processes such as morphogenesis during tissue development where biomolecules regulate key cell-fate decisions. In vivo, these factors are presented in a spatiotemporally tightly co ...

EPFL2012

In vitro lymphatic endothelial morphogenesis

Carolyn Yong Pullin

Cell organization into functional multicellular three-dimensional structures is a long-standing challenge. In particular, engineering of vascularized tissues requires both blood and lymphatic neovascular network formation in a simultaneous and coordinated ...

EPFL2011

Effect of Micromotion on Morphogen Dynamics in Peri-Implant Healing

Miguel Gortchacow

The primary stability of cementless femoral components is crucial for the long-term success of total hip arthroplasty. We know that the healing phase after surgery is a complex biological process, which is affected by the mechanical environment. Implant lo ...

EPFL2011