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Network Self-Organization Explains the Statistics and Dynamics of Synaptic Connection Strengths in Cortex
Related publications (65)
Principles of Network Plasticity in Neocortical Microcircuits
Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...
EPFL2023Long-term plasticity induces sparse and specific synaptic changes in a biophysically detailed cortical model
Eilif Benjamin Muller, Michael Reimann, James Gonzalo King, Marwan Muhammad Ahmed Abdellah, Pramod Shivaji Kumbhar, András Ecker, Sirio Bolaños Puchet, James Bryden Isbister, Daniela Egas Santander, Jorge Blanco Alonso, Giuseppe Chindemi, Ioannis Magkanaris
Synaptic plasticity underlies the brain’s ability to learn and adapt. This process is often studied in small groups of neurons in vitro or indirectly through its effects on behavior in vivo. Due to the limitations of available experimental techniques, inve ...
2023Engram cell connectivity as a mechanism for information encoding and memory function
Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...
Cambridge2023A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits: A congenital rat model
Disruption of brain development early in life may underlie the neurobiology behind schizophre-nia. We have reported more immature synaptic spines in the frontal cortex (FC) of adult Roman High-Avoidance (RHA-I) rats, a behavioural model displaying schizoph ...
2023Pathway and directional specificity of Hebbian plasticity in the cortical visual motion processing network
Friedhelm Christoph Hummel, Estelle Emeline Raffin, Michele Bevilacqua
Cortico-cortical paired associative stimulation (ccPAS), which repeatedly pairs single-pulse transcranial magnetic stimulation (TMS) over two distant brain regions, is thought to modulate synaptic plasticity. We explored its spatial selectivity (pathway an ...
2023Mesoscopic description of hippocampal replay and metastability in spiking neural networks with short-term plasticity
Tilo Schwalger, Valentin Marc Schmutz
Bottom-up models of functionally relevant patterns of neural activity provide an explicit link between neuronal dynamics and computation. A prime example of functional activity patterns are propagating bursts of place-cell activities called hippocampal rep ...
PUBLIC LIBRARY SCIENCE2022Fear Learning: An Evolving Picture for Plasticity at Synaptic Afferents to the Amygdala
Ralf Schneggenburger, Denys Osypenko, Shriya Palchaudhuri
Unraveling the neuronal mechanisms of fear learning might allow neuroscientists to make links between a learned behavior and the underlying plasticity at specific synaptic connections. In fear learning, an innocuous sensory event such as a tone (called the ...
SAGE PUBLICATIONS INC2022Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia
Objective: Depotentiation of homosynaptic plasticity of the primary motor cortex (M1) is impaired in patients with Parkinson's disease (PD) who have developed dyskinesias. In this exploratory study, we tested whether this holds true for heterosynaptic plas ...
ELSEVIER SCI LTD2022Mesoscopic population equations for spiking neural networks with synaptic short-term plasticity
Wulfram Gerstner, Tilo Schwalger, Valentin Marc Schmutz
Coarse-graining microscopic models of biological neural networks to obtain mesoscopic models of neural activities is an essential step towards multi-scale models of the brain. Here, we extend a recent theory for mesoscopic population dynamics with static s ...
2020The Mind Behind the Hebbian Synapse Donald O Hebb
How do neurons orchestrate behaviour? Let us trace our footsteps back to one of the first hypotheses proposing an alliance between the brain and behaviour. This article trace Donald Hebb's life, and how, in the neurophysiology milieu of the 20th century, h ...
SPRINGER INDIA2020