Publication

Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts

Related publications (32)

Mathematical modeling of bone formation inside tissue engineering scaffolds (Master project)

Tissue engineering scaffolds are porous structures that allow bone cells to reside and produce bone. This process involves migration and differentiation of mesenchymal stromal cells and production of cartilage and bone by chondrocytes and osteoblasts, whic ...

2010

The role of MYC in bone and in the hematopoietic stem cell niche

Maike Jaworski

The nuclear protein c-Myc is one of the most potent proto-oncogenes described. Its expression is found to be deregulated in more than 50 percent of human cancers, where it has been shown to control a number of biological processes including driving prolife ...

EPFL2009

Novel determinants of the hematopoietic microenvironment in development and homeostasis

Olaia Maria Naveiras Torres-Quiroga

The promise of regenerative medicine depends on succeeding at generating sufficient amounts of functional, transplantable tissue by reliably differentiating pluripotent stem cells through the paths of ontogeny, or by efficiently expanding adult stem cells ...

Harvard University2009

In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate

We describe herein some immunological properties of human fetal bone cells recently tested for bone tissue engineering applications. Adult mesenchymal stem cells and adult osteoblasts were included in the study for comparison. Surface markers involved in b ...

2009

In vivo evaluation of human fetal cells as allogenic cell source for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban, Corinne Scaletta

The aim of this study was to test the association of fetal bone cells with ceramic reinforced PLA scaffolds for tissue engineering. As animal models, the craniotomy and the femoral condyle approaches in rats were chosen to follow cortical and trabecular bo ...

2008

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban, Corinne Scaletta, Claire Diane Delabarde

Fetal bone cells were shown to have an interesting potential for therapeutic use in bone tissue engineering due to their rapid growth rate and their ability to differentiate into mature osteoblasts in vitro. We describe hereafter their capability to promot ...

2008

A novel cell culture approach for tissue engineering based on surface expansion

Hicham Majd

Most tissue engineering approaches include the delivery of reparative cells to a damaged host tissue. Generally these cells are sought to be of a stem cell character since they retain a high potential for proliferation and differentiation into diverse phen ...

EPFL2008

Fetal bone cells for tissue engineering

In this thesis, the potential use of fetal bone cells for tissue engineering was evaluated. At first, fetal bone cells were characterized in vitro regarding their proliferation rate, the induction of their osteoblastic phenotype, and their antigenicity. Th ...

EPFL2007

Biocompatibility of bioresorbable poly(L-lactic acid) composite scaffolds obtained by supercritical gas foaming with human fetal bone cells

Dominique Pioletti, Pierre-Etienne Bourban, Boris Hinz

The aim of this investigation was to test the biocompatibility of three-dimensional bioresorbable foams made of poly(L-lactic acid) (PLA), alone or filled with hydroxyapatite (HA) or beta-tricalcium phosphate (beta-TCP), with human primary osteoblasts, usi ...

2005

Fetal bone cells for tissue engineering

Dominique Pioletti, Corinne Scaletta, Pierre-François Leyvraz

We envision the use of human fetal bone cells for engineered regeneration of adult skeletal tissue. A description of their cellular function is then necessary. To our knowledge, there is no description of human primary fetal bone cells treated with differe ...

2004

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