Publications related to Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Hilal Lashuel, Bruno Claude Daniel Fauvet

Posttranslational modifications (PTMs) serve as molecular switches for regulating protein folding, function, and interactome and have been implicated in the misfolding and amyloid formation by several proteins linked to neurodegenerative diseases, includin ...

2015

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

Patrick Aebischer, Bernard Schneider

Alzheimer's disease is the most prevalent tauopathy and cause of dementia. We investigate the hypothesis that reactivation of plasticity can restore function in the presence of neuronal damage resulting from tauopathy. We investigated two models with tau h ...

2015

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Francesco Simone Ruggeri

Today, more than 40 million people worldwide are affected by neurodegenerative disorders. Onset of these diseases is associated with insoluble fibrillar protein aggregates, termed amyloids. The molecular origin and the link between amyloid formation and di ...

EPFL2015

Structural differences of amyloid-beta fibrils revealed by antibodies from phage display

Hilal Lashuel, Patrick Droste

Background: Beside neurofibrillary tangles, amyloid plaques are the major histological hallmarks of Alzheimer's disease (AD) being composed of aggregated fibrils of beta-amyloid (A beta). During the underlying fibrillogenic pathway, starting from a surplus ...

Biomed Central Ltd2015

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Philippe Renaud, Robert Meissner, Anja Kunze, Serena Brando

In vitro studies of Alzheimer’s disease are based on homogenously seeded neural cells. These studies reveal molecular pathway mechanism related to neurite degeneration, but they cannot analyze interactions between diseased and healthy cells. Furthermore, t ...

2011

The Gamma-Secretase-Mediated Proteolytic Processing of APP C-Terminal Fragments as a Therapeutic Target for Alzheimer's Disease

Jemila Houacine

Alzheimer's disease (AD) is a devastating neurodegenerative disorder which severely impairs cognitive functions by triggering neuronal cell death and synaptic loss, and finally leads the patients to death. Two main histopathological hallmarks can be found ...

EPFL2011

Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Philippe Renaud, Robert Meissner, Anja Kunze, Serena Brando

This communication presents a novel experi- mental model for Alzheimer studies, where connected pri- mary neurons were set into subtend, co-pathological states. Cortical neurons were cultured in two separated cell com- partments in a microfluidic device. A ...

Wiley-Blackwell2011

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Nucleation Dependent Polymerization of Amyloid-ß (Aß) as an Important Determinant of Aß Amyloid Formation and Neurotoxicity

Mohammad Asad Jan Qureshi

Aggregation and fibril formation of amyloid-β (Aβ) peptides play a pivotal role in the pathogenesis of Alzheimer's disease (AD). Aβ peptides, principally comprising of 40 or 42 amino acid residues (Aβ40 and Aβ42), are produced by proteolytic processing of ...

EPFL2010

Transmission and spreading of tauopathy in transgenic mouse brain

Tristan Bolmont

Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease(1). In the disease process, neuronal tau inclusions first appear in the transentorhinal cortex from where they se ...

Nature Publishing Group2009

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

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Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Structural differences of amyloid-beta fibrils revealed by antibodies from phage display

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

The Gamma-Secretase-Mediated Proteolytic Processing of APP C-Terminal Fragments as a Therapeutic Target for Alzheimer's Disease

Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Nucleation Dependent Polymerization of Amyloid-ß (Aß) as an Important Determinant of Aß Amyloid Formation and Neurotoxicity

Transmission and spreading of tauopathy in transgenic mouse brain

Structural differences of amyloid-beta fibrils revealed by antibodies from phage display

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

The Gamma-Secretase-Mediated Proteolytic Processing of APP C-Terminal Fragments as a Therapeutic Target for Alzheimer's Disease

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Transmission and spreading of tauopathy in transgenic mouse brain

Nucleation Dependent Polymerization of Amyloid-ß (Aß) as an Important Determinant of Aß Amyloid Formation and Neurotoxicity

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology