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Corrinoid auxotrophy in the obligate organohalide respiring Dehalobacter restrictus
Related publications (32)
Olfactory receptor pseudo-pseudogenes
Matteo Dal Peraro, Benoîte Bargeton
Pseudogenes are generally considered to be non-functional DNA sequences that arise through nonsense or frame-shift mutations of protein-coding genes(1). Although certain pseudogene-derived RNAs have regulatory roles(2), and some pseudogene fragments are tr ...
Nature Publishing Group2016Understanding the metabolism of tetrachloroethene-respiring Dehalobacter restrictus
Tetra- and trichloroethene (PCE, TCE) are organohalides polluting the environment as a result of inappropriate use, storage, and disposal by various industries. Anthropogenic pollution by organohalides is a major source of concern because of their undesira ...
EPFL2015Functional genomics of corrinoid starvation in the organohalide-respiring bacterium Dehalobacter restrictus strain PER-K23
Christof Holliger, Julien Maillard, Yue Lu, Aamani Rupakula Boyanapalli, Hauke Smidt
De novo comnoid biosynthesis represents one of the most complicated metabolic pathways in nature. Organohalide-respiring bacteria (OHRB) have developed different strategies to deal with their need of corrinoid, as it is an essential cofactor of reductive d ...
Frontiers Research Foundation2015Corrinoid auxotrophy in the obligate organohalide-respiring Dehalobacter restrictus strain PER-K23
Christof Holliger, Julien Maillard, Yue Lu, Aamani Rupakula Boyanapalli, Hauke Smidt
Background Corrinoids are an essential cofactor of reductive dehalogenases, the key enzymes of organohalide respiration (OHR). Dehalobacter restrictus is an obligate OHR bacterium (OHRB) able to conserve energy with tetrachloroethene, but is unable to de n ...
2014Corrinoid Auxotrophy in the Obligate Organohalide-Respiring Dehalobacter restrictus strain PER-K23
Christof Holliger, Julien Maillard, Yue Lu, Aamani Rupakula Boyanapalli, Hauke Smidt
Introduction: Corrinoids are an essential cofactor of reductive dehalogenases, the key enzymes of organohalide respiration (OHR). Dehalobacter restrictus strain PER-K23 is an obligate OHR bacterium able to conserve energy with tetrachloroethene, but is una ...
2014Proteome analysis of the response of Dehalobacter restrictus to cobalamin starvation
Christof Holliger, Julien Maillard, Aamani Rupakula Boyanapalli, Hauke Smidt
Dehalobacter restrictus strain PER-K23 is an obligate organohalide respiring microorganism known to solely use tetra- or trichloroethene as electron acceptors with H2 as electron donor. The catalytic enzyme, PceA, contains a corrinoid as cofactor, a trait ...
2014Salvage of the essential corrinoid cofactor in Dehalobacter restrictus
Christof Holliger, Julien Maillard, Yue Lu, Aamani Rupakula Boyanapalli, Sébastien Keller, Hauke Smidt
The corrinoid cofactor is essential for organohalide respiration (OHR), a bacterial metabolism assisting towards environmental depollution. Two different strategies for obtaining corrinoids, are used by OHR bacteria, either de novo biosynthesis or salvagin ...
2014Regulation of the Corrinoid Metabolism in Desulfitobacteria
Christof Holliger, Julien Maillard, Emmanuelle Rohrbach, Aurélie Duret
The corrinoid cofactor is essential to organohalide respiration (OHR) as key element in virtually all reductive dehalogenases. Desulfitobacteria, and more particularly D. hafniense, represent a group of versatile OHR bacteria able to produce corrinoids de ...
2014The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors
The cyclic AMP-dependent transcriptional regulator GlxR from Corynebacterium glutamicum is a member of the super-family of CRP/FNR (cyclic AMP receptor protein/fumarate and nitrate reduction regulator) transcriptional regulators that play central roles in ...
Public Library of Science2014Corrinoid auxotrophy in the obligate organohalide-respiring Dehalobacter restrictus
Christof Holliger, Aamani Rupakula Boyanapalli
Corrinoids (derivatives of vitamin B12) are an essential cofactor of reductive dehalogenases, the key enzymes involved in the environmental-friendly process of organohalide respiration (OHR). However, genomic and physiological analyses of obligate OHR bact ...
2013