Publication

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Related publications (60)

Duplications of hox gene clusters and the emergence of vertebrates

The vertebrate body plan is characterized by an increased complexity relative to that of all other chordates and large-scale gene amplifications have been associated with key morphological innovations leading to their remarkable evolutionary success. Here, ...

Academic Press Inc Elsevier Science2013

Hox genes are central to the specification of structures along the anterior-posterior body axis, and modifications in their expression have paralleled the emergence of diversity in vertebrate body plans. Here we describe the genomic organization of Hox clu ...

Nature Publishing Group2010

Segment number and axial identity in a segmentation clock period mutant.

Andrew Charles Oates

A species-specific number of segments is a hallmark of the vertebrate body plan. The first segmental structures in the vertebrate embryo are the somites, which bud sequentially from the growing presomitic mesoderm (PSM). The Clock and Wavefront model for s ...

2010

During development of the vertebrate body axis, Hox genes are transcribed sequentially, in both time and space, following their relative positions within their genomic clusters. Analyses of animal genomes support the idea that Hox gene clustering is essent ...

2009

Epigenetic temporal control of mouse Hox genes in vivo

Denis Duboule

During vertebrate development, the temporal control of Hox gene transcriptional activation follows the genomic order of the genes within the Hox clusters. Although it is recognized that this "Hox clock" serves to coordinate body patterning, the underlying ...

2009

The Hox complex - an interview with Denis Duboule. Interviewed by Richardson, Michael K

Denis Duboule

Denis Duboule is one of the most influential and highly-cited scientists in developmental biology. Born in Geneva in 1955, he holds dual Swiss and French nationality. His undergraduate studies in biology at the University of Geneva included research on mou ...

2009

Epigenetic control of hox genes collinear activation during vertebrate development

Denis Duboule

Hox genes encode transcription factors essential for patterning the anterior to posterior animal body axis. In vertebrates, these genes are arranged in clusters. During development, Hox genes are activated in a time sequence that follows their physical ord ...

Elsevier Science BV2009

Rostral and caudal pharyngeal arches share a common neural crest ground pattern

Denis Duboule

In vertebrates, face and throat structures, such as jaw, hyoid and thyroid cartilages develop from a rostrocaudal metameric series of pharyngeal arches, colonized by cranial neural crest cells (NCCs). Colinear Hox gene expression patterns underlie arch spe ...

2009

The potential role of Hox genes during vertebrate limb development was brought into focus by gene expression analyses in mice (P Dolle, JC Izpisua-Belmonte, H Falkenstein, A Renucci, D Duboule, Nature 1989, 342:767-772), at a time when limb growth and patt ...

2007

Genes belonging to both HoxA and HoxD clusters are required for proper vertebrate limb development. Mice lacking all, or parts of, Hoxa and Hoxd functions in forelimbs, as well as mice with a gain of function of these genes in the early limb bud, have help ...

2007

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