Publication

A role for angiopoietin-2 in organ-specific metastasis

,
2013
Journal paper

Abstract

Angiopoietin-2 (ANG2/ANGPT2) has recently emerged as a promising target for the inhibition of tumor metastasis. In this issue of Cell Reports, Minami et al. show that the calcineurin-NFAT pathway promotes pulmonary tumor metastasis by inducing ANG2 in the lung endothelium.

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A role for angiopoietin-2 in organ-specific metastasis

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Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

A LIGHTning Strike to the Metastatic Niche

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

A LIGHTning Strike to the Metastatic Niche