Publications related to A three-state model for the regulation of telomerase by TERRA and hnRNPA1

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells

Joachim Lingner, Rita Valador Fernandes

Telomeres are the nucleoprotein structures at the ends of linear chromosomes. Telomeres are transcribed into long non-coding Telomeric Repeat-Containing RNA (TERRA), whose functions rely on its ability to associate with telomeric chromatin. The conserved T ...

OXFORD UNIV PRESS2023

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

Joachim Lingner, Thomas Frédéric Lunardi, Marianna Feretzaki, Rita Valador Fernandes

Telomeres-repeated, noncoding nucleotide motifs and associated proteins that are found at the ends of eukaryotic chromosomes-mediate genome stability and determine cellular lifespan1. Telomeric-repeat-containing RNA (TERRA) is a class of long noncoding RNA ...

2020

Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors

Nako Nakatsuka, Yang Yang, Bowen Zhu

We detect short oligonucleotides and distinguish between sequences that differ by a single base, using label-free, electronic field-effect transistors (FETs). Our sensing platform utilizes ultrathin-film indium oxide FETs chemically functionalized with sin ...

2020

The yeast C/D box snoRNA U14 adopts a "weak" K-turn like conformation recognized by the Snu13 core protein in solution

Benjamin Marcel Daniel Rothé

Non-coding RNAs associate with proteins to form ribonucleoproteins (RNPs), such as ribosome, box C/D snoRNPs, H/ACA snoRNPs, ribonuclease P, telomerase and spliceosome to ensure cell viability. The assembly of these RNA-protein complexes relies on the abil ...

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER2019

Functional characterization of the TERRA transcriptome at damaged telomeres

Joachim Lingner, Jacques Rougemont, Antonio Porro, Julien Delafontaine, Sascha Feuerhahn

Telomere deprotection occurs during tumorigenesis and aging upon telomere shortening or loss of the telomeric shelterin component TRF2. Deprotected telomeres undergo changes in chromatin structure and elicit a DNA damage response (DDR) that leads to cellul ...

Nature Publishing Group2014

Structure of active dimeric human telomerase

Joachim Lingner

Telomerase contains a large RNA subunit, TER, and a protein catalytic subunit, TERT. Whether telomerase functions as a monomer or dimer has been a matter of debate. Here we report biochemical and labeling data that show that in vivo-assembled human telomer ...

Nature Publishing Group2013

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

Jérôme Waser, Fides Benfatti, Florian Patrick Marie Daniel De la Barre De Nanteuil

The first method for the [3 + 2] annulation of donor acceptor aminocyclopropanes with aldehydes is reported. The reaction is catalyzed by iron trichlorlde on alumina in yields up to 99% and with excellent cis selectivities (up to >20:1) and represents a st ...

American Chemical Society2012

The human CST complex is a terminator of telomerase activity

Joachim Lingner, Sophie Redon, Liuh-Yow Chen

The lengths of human telomeres, which protect chromosome ends from degradation and end fusions(1,2), are crucial determinants of cell lifespan(3). During embryogenesis and in cancer, the telomerase enzyme counteracts telomeric DNA shortening. As shown in c ...

Nature Publishing Group2012

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A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Regulation and impact of TERRA R-loops at human telomeres

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors

The yeast C/D box snoRNA U14 adopts a "weak" K-turn like conformation recognized by the Snu13 core protein in solution

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA

Functional characterization of the TERRA transcriptome at damaged telomeres

Structure of active dimeric human telomerase

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

The human CST complex is a terminator of telomerase activity

Graph Chatbot

Chat with Graph Search

Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors

Regulation and impact of TERRA R-loops at human telomeres

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA

Structure of active dimeric human telomerase

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

The human CST complex is a terminator of telomerase activity

The yeast C/D box snoRNA U14 adopts a "weak" K-turn like conformation recognized by the Snu13 core protein in solution

Functional characterization of the TERRA transcriptome at damaged telomeres