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Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat
Related publications (41)
Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1
Kristina Schoonjans, Petar Petrov
Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...
Amsterdam2024Inverse Problems in Pulse-Echo Ultrasound: Exploiting Coherence for Image Enhancement and Quantitative Imaging
Whereas pulse-echo ultrasound imaging relied on focused acoustic waves since its inception, the last two decades have seen the development of techniques based on unfocused waves, including ultrafast ultrasound imaging. In large part due to the emergence of ...
EPFL2024Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy
The natural compound Cyclo Histidine-Proline (CHP) was initially discovered in the brain, but thereafter evaluated in the context of diabetes because of its hypoglycemic action. The pharmacokinetics and the toxicological profile of CHP showed it can be dos ...
EPFL2023New insights into rodent brain microstructure and metabolism in hepatic encephalopathy
Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...
EPFL2023High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study
Lijing Xin, Cristina Ramona Cudalbu, Bénédicte Marie Maréchal, Sarah Lachat
Background: There is increasing evidence that children or young adults having acquired liver disease in childhood display neurocognitive impairment which may become more apparent as they grow older. The molecular, cellular and morphological underpinnings o ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2023Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression
The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...
EPFL2022Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance
A simple predictive biomarker for fatty liver disease is required for individuals with insulin resistance. Here, we developed a supervised machine learning-based classifier for fatty liver disease using fecal 16S rDNA sequencing data. Based on the Kangbuk ...
NATURE PORTFOLIO2022Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data
Oxidative stress is a natural phenomenon in the body. Under physiological conditions intracellular reactive oxygen species (ROS) are normal components of signal transduction cascades, and their levels are maintained by a complex antioxidants systems partic ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2022Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology
Kristina Schoonjans, Hadrien Charles Edouard Demagny, Yu Sun
Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...
2021Space-time logic of liver gene expression at sub-lobular scale
Felix Naef, Clémence Yumie Syloun Hurni, Colas Noé Droin
The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones performing distinct functions. The liver is also subject to extensive tempo ...
NATURE RESEARCH2021